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Discovery offers hope for anti-cancer therapy
Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen.

Immunoglobulin E antibodies could fight cancer in humans and dogs

Antibodies that are produced in response to allergens could offer hope for a new anti-cancer therapy in dogs and humans, scientists have said.

Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen, such as pollen. However, their original purpose is to repel harmful external substances.  

A team of international scientists have now developed a ‘canine IgE’ that targets the EGFR growth factor in cancerous tumours. In-vitro studies found that, in more than 60 per cent of cases, the tumour was destroyed by IgE antibodies.

IgE antibodies build a ‘bridge’ between EGFR on cancer cells and inflammatory cells, which releases tumour necrosis factors.

The study, published in the Journal of Allergy and Clinical Immunology, offers hope for humans too, as canine and human EGFR are a 92 per cent match.

Lead author Erika Jensen-Jarolim said: "We can therefore hope that we have made an important contribution towards developing a new form of immunotherapy against cancerous tumours.

"A subsequent clinical trial will be conducted in canine patients to validate the results in an international joint initiative before moving to human trials.”

Image © M. Bernkopf/Vetmeduni Vienna

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AWF Student Grant open for submissions

News Story 1
 Applications are open for the Animal Welfare Foundation (AWF) Student Grant Scheme for innovative research projects designed to impact animal welfare.

Undergraduate and postgraduate students of veterinary science, veterinary nursing, agriculture studies and animal welfare are invited to submit their proposals to undertake research projects next year.

Grants are decided based on the project’s innovation, relevance to topical animal welfare issues and ability to contribute towards raising animal welfare standards. For more information visit animalwelfarefoundation.org.uk.  

Click here for more...
News Shorts
SPANA film highlights plight of working animals overseas

Animal welfare charity SPANA (The Society for the Protection of Animals Abroad) has teamed up with Brian Blessed and other famous voices to highlight the plight of working animals overseas.

In a new animated film, the celebrities raise awareness by showing the solidarity of the UK's own working animals on strike. A sniffer dog (Brian Blessed), police horse (Peter Egan) and sheepdog (Deborah Meaden) are shown ignoring their duties and protesting in solidarity with animals in developing countries.

SPANA chef executive Geoffrey Dennis said: "We are so grateful to Deborah, Peter and Brian for lending their voices to our new film, and for speaking up for millions of working animals overseas. SPANA believes that a life of work should not mean a life of suffering, and it is only thanks to people’s generosity and support that we can continue our vital work improving the lives of these animals."