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Discovery offers hope for anti-cancer therapy
Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen.

Immunoglobulin E antibodies could fight cancer in humans and dogs

Antibodies that are produced in response to allergens could offer hope for a new anti-cancer therapy in dogs and humans, scientists have said.

Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen, such as pollen. However, their original purpose is to repel harmful external substances.  

A team of international scientists have now developed a ‘canine IgE’ that targets the EGFR growth factor in cancerous tumours. In-vitro studies found that, in more than 60 per cent of cases, the tumour was destroyed by IgE antibodies.

IgE antibodies build a ‘bridge’ between EGFR on cancer cells and inflammatory cells, which releases tumour necrosis factors.

The study, published in the Journal of Allergy and Clinical Immunology, offers hope for humans too, as canine and human EGFR are a 92 per cent match.

Lead author Erika Jensen-Jarolim said: "We can therefore hope that we have made an important contribution towards developing a new form of immunotherapy against cancerous tumours.

"A subsequent clinical trial will be conducted in canine patients to validate the results in an international joint initiative before moving to human trials.”

Image © M. Bernkopf/Vetmeduni Vienna

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Hill's Vet Nurse Awards 2020 - get your nominations in!

News Story 1
 Hill's Pet Nutrition are reminding all veterinary nurses and veterinary practices to submit their entries for its 'Pet Slimmer of the Year' competition, 'Managing Weight with Excellence Competition' and the 'Senior Support Nurse of the Year Competition'.

The deadline for the 'Senior Support Nurse of the Year' competition closes on 6 September 2020, while the other competitions will remain open until 14 September 2020. All finalists will have the chance to win up to 500 worth of Love to Shop Vouchers.

To see full terms & conditions or to enter the awards click here

Click here for more...
News Shorts
Webinar highlights increasing threat of Angiostrongylus vasorum and other nematodes

CPD provider elearning.vet has launched a free webinar highlighting the increasing threat of Angiostrongylus vasorum and other nematodes to human and animal health. Hosted by parasitologist Dr Ian Wright, head of ESCAAP UK, the webinar also discusses the most effective treatment and prevention strategies.

Dr Wright said: "With surveys showing deworming frequencies below those recommended by ESCCAP and concerns surrounding over treatment of cats and dogs, there has never been a more important time to examine the importance of routine roundworm prevention. Without adequate control of Toxocara canis and Angiostronglyus vasorum, the impact on owners and their pets can be considerable."