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Discovery offers hope for anti-cancer therapy
Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen.

Immunoglobulin E antibodies could fight cancer in humans and dogs

Antibodies that are produced in response to allergens could offer hope for a new anti-cancer therapy in dogs and humans, scientists have said.

Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen, such as pollen. However, their original purpose is to repel harmful external substances.  

A team of international scientists have now developed a ‘canine IgE’ that targets the EGFR growth factor in cancerous tumours. In-vitro studies found that, in more than 60 per cent of cases, the tumour was destroyed by IgE antibodies.

IgE antibodies build a ‘bridge’ between EGFR on cancer cells and inflammatory cells, which releases tumour necrosis factors.

The study, published in the Journal of Allergy and Clinical Immunology, offers hope for humans too, as canine and human EGFR are a 92 per cent match.

Lead author Erika Jensen-Jarolim said: "We can therefore hope that we have made an important contribution towards developing a new form of immunotherapy against cancerous tumours.

"A subsequent clinical trial will be conducted in canine patients to validate the results in an international joint initiative before moving to human trials.”

Image © M. Bernkopf/Vetmeduni Vienna

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New online dental resource for vets and horse owners

News Story 1
 The British Equine Veterinary Association (BEVA) has launched a new online dental resource for vets and horse owners.

The veterinary section of the resource is aimed at primary practice equine vets who are performing dentals for clients as part of a routine care programme. Information includes 'how to perform a thorough oral exam,' guidelines for charting, and a list of BEVA equine vets with postgraduate qualifications in equine dentistry.

Free to BEVA members, the new resource is supported by a range of practical courses, veterinary CPD, workshops and webinars. To find out more visit the BEVA website 

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News Shorts
Vet school runs event for aspiring vets and nurses

Bristol Veterinary School is hosting an event for aspiring vets and vet nurses, to allow them to experience life as a student and find out what itís like to work in veterinary medicine. The one-day event, called VetQuest, will be held at the Langford Campus and includes a tour, talks on admissions and work experience, and the chance to take part in practical sessions. Taking place on Saturday 27 October, the event is primarily aimed at 11-12 year olds and costs £50, including lunch. There are a limited number of subsidised tickets for £10. To book, visit VetQuest 2018