Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

New insights into link between high insulin levels and laminitis
Acute endocrine laminitis is seen when ponies and some horses graze lush pasture or consume a diet that is rich in sugar or starch.

Antibody could aid development of new preventative drugs 

Scientists say they have shed new light on the link between high levels of insulin and equine laminitis.

It has been known for some time that high insulin levels can cause acute endocrine laminitis - the most common form of the condition - which is seen when ponies and some horses graze lush pasture or consume a diet that is rich in sugar or starch.

However, the mechanism by which insulin can produce effects in the foot leading to laminitis has been the subject of much debate in recent years. Scientists have previously been confused by the fact that insulin must interact with a specific receptor on the surface of cells to product an effect, but there do not appear to be any insulin receptors on hoof lamellar cells.

Researchers from the University of Melbourne and WALTHAM Equine Studies Group looked at the effect of insulin on equine hoof lamellar cells in the laboratory, exploring the similarities between insulin and a growth factor hormone called insulin-like growth factor -1 (IGF-1).

There are receptors for IGF-1 on the lamellar cells and the research team found high levels of insulin stimulated the cells to proliferate. In addition, this effect could be prevented with an antibody that specifically blocks just the IGF-1 receptor.

Changes within the cells were mainly linked to very high concentrations of insulin. Such concentrations are not commonly seen in normal horses considered to be at lower risk of laminitis, but can be seen in those with insulin dysregulation linked to equine metabolic syndrome.

Future research will look at how these cellular changes might cause laminitis, but researchers said it appears that targeting IGF-1 receptors may help with the development of new drugs to prevent laminitis.

Image © Spillers
 

Become a member or log in to add this story to your CPD history

Endangered turtles rescued from smugglers

News Story 1
 A group of endangered turtles have found a new home at London Zoo after being rescued from smugglers.

The four big-headed turtles arrived at the zoo at the end of last year, after smugglers tried to illegally import them to Canada, labelled as toys.

One of the turtles, named Lady Triệu after a Vietnamese warrioress, has moved to a new exhibit in the zoo’s reptile house. She is the only one of her kind in a UK zoo.

Big-headed turtles have such large heads that they cannot pull them back into their shells. To compensate, they have armour plating from head to tail and a very sharp beak to fend off predators. They are ranked number 18 on ZSL’s EDGE of Existence reptile list, which puts threatened species at the forefront of conservation action. Image © ZSL  

Click here for more...
News Shorts
Professor Abdul Rahman announced as keynote speaker for BVA Members’ Day 2019

Celebrated Indian vet and parasitologist Professor Abdul Rahman is set to deliver the keynote speech at BVA Members’ Day 2019.

Professor Rahman will present his insights into the human behaviour challenges of controlling zoonotic disease in his talk: ‘A One Health approach to rabies elimination in Asia’. The talk will outline efforts to gain political support for dog vaccination programmes in China, as well as the need for a collaborative approach between vets, public health, livestock and animal welfare agencies.

The event takes place on Thursday, 19 September at Brangwyn Hall, Swansea. Tickets are free but must be reserved through the BVA website as places are limited.