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‘Trojan horse’ antibiotic shows promise
"Our results support cefiderocol as a novel approach that might be used to overcome Gram-negative resistance." (Stock photo)
Drug works by tricking bacteria in allowing it to enter 

A new antibiotic that acts like the Trojan horse in Greek legend has shown promise in phase two trials, scientists have said.

Cefiderocol works by tricking bacteria in allowing it to enter. It was found to be as effective as the current standard-of-care antibiotic, in the treatment of complicated urinary tract infections (UTIs) caused by several multi-drug-resistant Gram-negative bacteria.

Findings published in The Lancet Infectious Diseases journal suggest that patients treated with cefiderocol had a higher and more sustained level of pathogen eradication; and similar clinical outcomes to those treated with imipenem-cilastatin.

The study randomised 448 adults who had been hospitalised with a complicated UTI or uncomplicated pyelonephritis. Three hundred patients received three daily infusions of cefiderocol for seven to 10 days, while the remainder were given imipenem-cilastatin.

Seven days after treatment stopped, cefiderocol showed efficacy rates of 73 per cent and 55 per cent respectively for clinical and microbiological responses.

Lead author Dr Simon Portsmouth, from Shionogi Inc, said: "Cefiderocol was found to be both safe and tolerable in a population of older patients who were very ill with complex comorbid conditions and a wide range of multidrug-resistant pathogens. Our results support cefiderocol as a novel approach that might be used to overcome Gram-negative resistance.

"Ongoing clinical trials of pneumonia, including hospital-acquired pneumonia and ventilator-associated pneumonia, and a study in patients with carbapenem-resistant infections, will provide additional important information about cefiderocol."

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Hen charity starts work on first rehoming centre

News Story 1
 The British Hen Welfare Trust (BHWT) has begun work on its first hen welfare and education centre. Located in north Devon, the 250 square metre building will comprise a state-of-the-art rehoming centre and fully equipped veterinary clinic.

Image © Guy Harrop  

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Former RCVS president to chair new Horse Welfare Board

Former RCVS president Barry Johnson has been appointed as the independent chair of a new Horse Welfare Board. Barry, who is also past chairman of World Horse Welfare, was selected by an industry panel including the British Horseracing Authority, the Racecourse Association and The Horsemen’s Group.

The welfare board aims to develop a new welfare strategy covering the whole racing industry. Mr Johnson said: “I’m very pleased to have been asked by racing to take on this role and by the sport’s commitment to continuous improvement in the welfare of racehorses."