Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Pirbright research to make vaccines more accessible
Pirbright research could boost vaccine yields by up to tenfold. 
Scientists to use gene-editing technology to remove major barrier to viral replication

Livestock vaccines may soon be more accessible and affordable thanks to funding from the Livestock Vaccine Innovation Fund.

The funding has been awarded to the Pirbright Research Institute to allow previous immune response research to continue. The research will involve using gene-editing technology to remove chiFITM proteins in chicken cells - one of the major barriers to viral replication - and could boost vaccine yields by up to tenfold.

Dr Mark Fife from Pirbright's Genetics and Genomics Group, which is leading the research, explains: “Many vaccines for both animal and human, are produced by going a weakened form of the virus in chicken eggs or cells, which are then extracted for use.

“Although chiFITM may help protect chickens from viral infection, the protein actually hinders vaccine productions, as it prevents the weakened virus from replicating at high levels and reduces the amount of vaccine that can be made.

"Our new research will involve using a gene-editing system called CRISPR/Cas9 to remove the chIFITM genes in chicken cells, therefore overcoming one of the barriers for viral replication, and boosting the levels of vaccine virus produced.”

This boost to vaccine production will make vaccines cheaper to produce and more accessible to livestock owners in developing nations. The scientists will first focus on increasing flu vaccine yields, but the method could also be applied to multiple livestock diseases and potentially human diseases too.

When the researchers have piloted the technique, they will work with commercial partners Horizon Discovery Group plc to bring this new technology to market. It is hoped the technology will commercially available as soon as 2021. 

Become a member or log in to add this story to your CPD history

New app to improve street dog welfare

News Story 1
 A new free app will support vital work in clinics caring for stray dogs around the world, experts say. Created by the University of Edinburgh, the tool allows vets to track the wellbeing of dogs going through catch-neuter-return schemes, which are common in countries with large numbers of strays.

Vets say the welfare of individual dogs can be overlooked during the process of capture, transport or surgery. The app, piloted across Asia and Africa, helps staff to monitor welfare, spot signs of distress and develop strategies to improve care. It was launched at BSAVA Congress on Friday 6 April.  

Click here for more...
News Shorts
Farm to fork traceability championed in new service

Defra has created a new information service to offer farm to fork traceability when the UK leaves the EU. The Livestock Information Service, which is set to be operational from 2019, will identify and track animal movements via electronic IDs, meaning the industry and government are better placed to respond in the event of a disease outbreak.

Environment secretary Michael Gove said: “This service will be instrumental in improving traceability and providing guarantees to consumers about the origin of their food. NFU President Minette Batters, among others, has helped lead the way on this, showing how it will drive a progressive and vibrant livestock industry once we leave the EU.”