Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Bacteria develop resistance from rivals - study
The overuse of antibiotics may not be exclusively responsible for antibiotic resistance.

Research works to tackle antibiotic resistance

The overuse of antibiotics may not be exclusively responsible for antibiotic resistance, according to new research.

The study by the University of Basel found that bacteria can develop resistance to antibiotics from their competitors.
Writing in Cell Reports, researchers show that some bacteria inject a toxic cocktail into their rivals leading to cell lysis and death.

Researchers also found that if the released material contains certain drug-resistant genes, the specific resistance can be bestowed upon the new owner. As such, the antibiotic is no longer effective and the bacteria can reproduce.

“Some of these toxic proteins kill the bacterial competition very effectively, but do not destroy the cells,” explained Professor Marek Basler, who led the research. “Others severely damage the cell envelope, which leads to less of the attacked bacteria and hence the release of its genetic material.”

In the study, the researchers analysed the drug-resistant bacterium Acinetobacter baumanni - a typical hospital germ that originated during the Iraq war. The bacteria is also known as the ‘Iraq bug’ because it was spread by American soldiers returning home from combat.

The team found that the emergence and spread of multidrug resistance could be attributed - amongst other things - to the skills of certain bacteria. First, the bacteria combat their rivals by injecting them with toxic proteins - or effectors - using the type VI secretion system (T6SS), a poison syringe. Second, they are able to uptake and reuse the released genetic material.

In the model Acinetobacter baylyi, a close relative of the Iraq bug, Professor Basler’s team identified five differently acting toxic effectors.

“For the bacteria it makes absolute sense to produce not only a single toxin, but a cocktail of various toxins with different effects,” Basler explains. “This increases the likelihood that the rival can be successful and in some cases also lysed to release their DNA.”

Professor Basler added that the T6SS 'can also be found in other pathogens such as those which cause pneumonia or cholera'.

Become a member or log in to add this story to your CPD history

Nominations for 2019 RSPCA Honours Awards now open

News Story 1
 People across the UK are being urged to nominate a standout animal champion for the 2019 RSPCA Honours Awards.

The awards recognise those who have worked tirelessly to improve animal welfare, campaigned on behalf of animals, or shown true bravery. Previous winners include comedian John Bishop, who was awarded Celebrity Animal Champion of the Year, and 11-year-old Lobby Cantwell, who raised more than £1,000 for the charity through mountain climbs and bike rides.

To submit a nomination or find out more about the awards visit the RSPCA website. Nominations will remain open until 4 pm on Friday, March 15.  

Click here for more...
News Shorts
New £1m project to investigate dairy cow lameness

Scotland’s Rural College (SRUC) is leading a new £1 million research project to investigate the causes of lameness in dairy cows.

One in three dairy cows are affected by lameness every day in the UK, costing the industry an estimated £250 milion annually.

The project will take three years to complete and is due to finish by November 2021.

Professor Georgios Banos of SRUC commented: “In addition to pain and discomfort to the animal, lameness is associated with decreased milk production and inflated farm costs.

“Among cows raised in the same environment, some become lame while others do not. Understanding the reasons behind this will help us develop targeted preventive practices contributing to enhanced animal welfare and farm profitability.”