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Immune system ‘could aggravate BRSV’
Scientists say large numbers of neutrophils contribute to some of the short term clinical signs associated with BRSV.
Decreasing neutrophil response could improve clinical signs - study  

Immune cells designed to clear infections could worsen respiratory disease caused by bovine respiratory syncytial virus (BRSV), according to new research.

The team of international scientists behind the study are the first to simultaneously examine hundreds of proteins that are involved in the response of calves to BRSV, which infects the lungs of cattle.

Findings published in PLOS ONE suggest there is a link between the numbers of immune cells, or neutrophils, clinical signs of disease, lung tissue damage and the amount of virus in the lungs of infected calves.

It is thought that neutrophils aid the clearance of of BRSV - and the closely related human respiratory syncytial virus (HRSV) - by removing infected cells. When they appear in excessive numbers, however, they appear to have the opposite effect, releasing harmful substances that destroy the lung and block the airways.

Scientists say large numbers of neutrophils contribute to some of the short term clinical signs associated with BRSV, such as breathing problems.

An exaggerated neutrophil response can also result in longer-term effects, the study suggests. This is down to their ability to remodel lung tissue, which increases the time it takes for clinical signs to clear, even after the virus has been eliminated. In severe and early human RSV infections, it is thought that over-stimulation of neutrophils could increase the likelihood of asthma.

Dr Geraldine Taylor, honorary fellow at Pirbright Institute, said: “Our findings suggest treatments that decrease the response of neutrophils could improve clinical signs both in the short and long term.”

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New online dental resource for vets and horse owners

News Story 1
 The British Equine Veterinary Association (BEVA) has launched a new online dental resource for vets and horse owners.

The veterinary section of the resource is aimed at primary practice equine vets who are performing dentals for clients as part of a routine care programme. Information includes 'how to perform a thorough oral exam,' guidelines for charting, and a list of BEVA equine vets with postgraduate qualifications in equine dentistry.

Free to BEVA members, the new resource is supported by a range of practical courses, veterinary CPD, workshops and webinars. To find out more visit the BEVA website 

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News Shorts
Vet school runs event for aspiring vets and nurses

Bristol Veterinary School is hosting an event for aspiring vets and vet nurses, to allow them to experience life as a student and find out what it’s like to work in veterinary medicine. The one-day event, called VetQuest, will be held at the Langford Campus and includes a tour, talks on admissions and work experience, and the chance to take part in practical sessions. Taking place on Saturday 27 October, the event is primarily aimed at 11-12 year olds and costs £50, including lunch. There are a limited number of subsidised tickets for £10. To book, visit VetQuest 2018