Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Multi-species study reveals new insights into OCD
Canine OCD normally manifests as excessive licking, sucking, or tail chasing.

Researchers identify new genes associated with the disorder

A study by US scientists has revealed new insights into the genetics underlying obsessive-compulsive disorder (OCD) in humans and animals.

Researchers at the Broad Institute, Massachusetts, compared genetic information across multiple species that suffer from compulsive behaviour disorders and found four new genes with OCD-variants in humans.

The genes are thought to disrupt synapse development and throw neural pathways in the brain out of balance. The data is published in the journal Nature Communications.

OCD is a mental health disorder that affects some 80 million people worldwide. Obtained by inheritance, the biology of the disorder is still poorly understood.

To better understand the disorder, the team compiled a list of genetic associations from previous studies of human and animal OCD. The team used the data to refine a list of more than 600 genes and 80,000 related regulatory elements that might be involved in human OCD.

As part of the study, the researchers assessed genetic studies of canine OCD, which normally manifests as excessive licking, sucking, or tail chasing.

“We were seeking ways to take advantage of information from other species in order to inform and focus the study in humans,” explained study author Hyun Ji Noh. “Each additional species that we looked at gave us more information about possible factors in the brain that contribute to OCD.”

The four genes identified by the team - NRXN1, HTR2A, CTTNBP2 and REEP3 - all showed variants in either protein-coding or regulatory DNA significantly associated with human OCD.

Researchers say the data suggest new targets to pursue an improved biological and therapeutic understanding of OCD.

Image (C) Lil Shepherd.

Become a member or log in to add this story to your CPD history

Giraffe Conservation Foundation named BVNA’s charity of the year

News Story 1
 BVNA president Wendy Nevins has named The Giraffe Conservation Foundation as the association’s charity of the year for 2017/2018.

The Giraffe Conservation Foundation dedicates its work to a sustainable future for wild giraffe populations. Wendy Nevins said: ‘I have chosen the Giraffe Conservation Foundation for the BVNA Charity of the Year because I have always thought Giraffes were magnificent animals.

‘I also think it is important that we look at the wider issue of conservation and education across all species.’  

News Shorts
Scientists win award for openness in animal research

UK scientists have won an award for the 360ş Laboratory Animal Tours project, which offered the public an online, interactive tour of four research facilities that are usually restricted access.

The project won a public engagement award at the Understanding Animal Research (UAR) Openness Awards, which recognise UK research facilities for transparency on their use of animals in research, as well as innovation in communicating with the public.

The tour was created by the Pirbright Institute, the University of Oxford, the University of Bristol and MRC Harwell Institute.