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Study reveals how morbillivirus can adapt to infect humans
Scientists used ground-breaking techniques to reveal that small ruminant morbillivirus can adapt to infect human cells.

Researchers use novel techniques to identify changes

Researchers at The Pirbright Institute have used ground-breaking techniques to reveal that the small ruminant morbillivirus can adapt to infect human cells.

The study, published in the Journal of Virology, found that small ruminant morbillivirus (also known as Peste des petits ruminants (PPR)) could, through minor changes in a particular protein, overcome barriers that prevent it from entering human cells.

Researchers say the findings have important implications for monitoring virus evolution in the field, particularly during eradication campaigns.
Equally important, however, were the techniques used to identify the changes. Scientists say the method eliminated the need for live infectious virus and high containment laboratories, and meant modified live virus with potential zoonotic capability were not generated.

Dr Dalan Bailey who led the research explains: “By examining the zoonotic potential of non-human morbilliviruses we identified that PPRV cannot enter human cells because it does not have the correct attachment protein configuration to bind to the human SLAMF1 immune cell receptor. 

“However, using our existing understanding of how these proteins interact, and previous sequencing and structural studies, we were able to identify and confirm that a single amino acid in the PPRV Haemagglutinin can overcome this barrier to entry.”

He added: “It is important to note that this does not mean the virus would have the potential to cause disease in humans as there are many other factors required for the virus to successfully replicate and cause clinical symptoms, but it does indicate that these viruses have zoonotic potential given the right mutations and conditions.

“In the light of these findings we believe it is important that a sequence surveillance programme, similar to that undertaken for influenza, is introduced to monitor mutations in this region.”

The study was carried out in collaboration with the University of Glasgow, the University of Cambridge and other institutions.

 

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RCVS carries out annual VN CPD audit

News Story 1
 The RCVS is carrying out its annual veterinary nurse CPD audit and has sent out requests for the CPD records of more than 1,100 nurses this week.

Under the RCVS Code of Professional Conduct, nurses are required to carry out at least 45 hours of CPD over a rolling three-year period. This year, 1,130 nurses have been asked to share their records from 2016-2018 to show that they have complied with the requirements.

Earlier this year, the VN Council decided to expedite the referral process for nurses who have not complied with the CPD requirement for three or more years. In such cases nurses will have their records sent to the CPD Referral Group. 

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News Shorts
Kew Gardens seeking vets for Ethnoveterinary Medicine Project

A new project at the Royal Botanical Gardens, Kew, is seeking the help of vets to find out how plants were traditionally used to treat animals.

The Ethnoveterinary Medicine Project is aiming to record the remaining knowledge from across the British Isles, before it disappears.

Visit the Kew Gardens website for more information or email ethnovet@kew.org to share data.