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'Broccoli drug' may treat osteoarthritis
broccoli
The beneficial effects of broccoli are due to sulforaphane, a compound released during digestion.

Positive results for new drug tested at the RVC

A chemical found in broccoli could offer a treatment for osteoarthritis, after a new drug has been successfully trialled for the first time at the Royal Veterinary College (RVC).

Eating cruciferous vegetables such as sprouts, cabbages and particularly broccoli has been found to ease the symptoms of osteoarthritis. However, patients would have to eat a substantial amount each day to see any real benefits.

The advantages of broccoli are due to sulforaphane, a compound released from the vegetable during digestion, which blocks certain enzymes that destroy joint cartilage. It also obstructs processes that cause the inflammation linked to osteoarthritis.

It had proved impossible to manufacture sulforaphane into a regular pill as it is an unstable molecule.

However, working alongside the RVC, UK pharmaceutical company Evgen Pharma has developed a stable, synthetic version of the compound and incorporated it into a new medicine called Sulforadex (SFX-01). Just a single dose of this medication provides as much sulforaphane as 2.5kg of broccoli.

Osteoarthritis affects nearly nine million people in the UK, costing the NHS over £5 billion a year. Other than pain relief and joint replacement, there is currently no effective treatment or cure. The RVC's professor of skeletal dynamics, Andrew Pitsillides said there is "massive" potential for SFX-01.

For the first time, the product has been trialled by the RVC using live laboratory mice prone to osteoarthritis.

Osteoarthritic mice treated with SFX-01 were shown to have substantially improved movement, gait balance and bone architecture, compared with the control group that did not receive treatment.

“These initial results are very positive for such an experiment and we have convinced ourselves that sulforaphane is a promising agent for the treatment of osteoarthritis," said Prof Pitsillides.

“However, the clinical development of sulforaphane has been held back by the fact that it is inherently unstable. Thus, SFX-01 is a major advance in this area.”

Further pre-clinical and then human clinical trials are needed now that the product is seen as a viable treatment for the painful joint condition.

Human trials are already underway to further investigate the anti-cancer and anti-inflammatory properties of sulforaphane.

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Practices urged to audit neutering data

News Story 1
 RCVS Knowledge has called on vet practices to audit their post-operative neutering outcomes.

It follows the release of the 2024 NASAN benchmarking report, which collates data from neutering procedures performed on dogs, cats and rabbits.

The benchmarking report enables practices in the UK and Ireland to compare their post-operative outcomes to the national average. This includes the rate of patients lost to follow-up, which in 2024 increased to 23 per cent.

Anyone from the practice can submit the data using a free template. The deadline for next report is February 2026.

Visit the RCVS Knowledge website to complete an audit. 

Click here for more...
News Shorts
New guidance for antibiotic use in rabbits

New best practice guidance on the responsible use of antibiotics in rabbits has been published by the BSAVA in collaboration with the Rabbit Welfare Association & Fund (RWA&F).

The guidance is free and has been produced to help veterinary practitioners select the most appropriate antibiotic for rabbits. It covers active substance, dose and route of administration all of which are crucial factors when treating rabbits owing to the risk of enterotoxaemia.

For more information and to access the guide, visit the BSAVALibrary.