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Rapid evolution may have helped bats avoid cancer, study finds
The researchers sequenced the genomes of the Jamaican fruit bat (pictured) and the Mesoamerican mustached bat.

It may also help them tolerate viruses.
 

A study has suggested that rapid evolution may be the reason why bats are able to avoid cancer, and also tolerate viral infections like SARS-CoV-2.

The researchers aimed to investigate bats’ low cancer rates and robust immune system, with the theory that it may have implications for human health. For example, performing comparative genomic analysis of bats against mammals that are susceptible to cancer may lead to new discoveries on the causes of cancer, and its links with immunity.

It could also further our understanding of why bats are tolerant to zoonotic viruses, such as SARS-CoV-2, before they get passed onto humans. This could lead to work that may better prevent disease outbreaks from animals to people.

The investigation involved the researchers using the Oxford Nanopores Technologies long-read platform to sequence the genomes of two bat species, the Jamaican fruit bat and the Mesoamerican mustached bat, which have key evolutionary positions.

They then conducted a comparative genomic analysis with a diverse collection of bats and other mammals.

This found genetic adaptations in six DNA repair-related proteins and 46 proteins in bats that were cancer-related. It revealed that these altered cancer-related genes were twice as enriched in the bats compared to other mammals.

The analysis identified antiviral genes that showed evidence of rapid evolution. There were also positive selection signs in 33 tumour suppressors and 6 DNA-repair genes which may contribute to bats’ increased longevity and reduced cancer rates.

This shows that the immune systems of bats rely on bat-wide and lineage-specific evolution among their genes, which suggests diverse immune strategies.

Armin Scheben, the lead author, said: “By generating these new bat genomes and comparing them to other mammals we continue to find extraordinary new adaptations in antiviral and anticancer genes,

“These investigations are the first step towards translating research on the unique biology of bats into insights relevant to understanding and treating aging and diseases, such as cancer, in humans.”

The full study can be found in the Genome Biology and Evolution journal.

Image © Shutterstock

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New guidelines published for wildlife disease surveillance

News Story 1
 A set of international guidelines for disease surveillance in wildlife has been updated for the first time since 2015.

Released by the International Union for Conservation of Nature and the World Organisation for Animal Health, General Guidelines for Surveillance of Diseases, Pathogens and Toxic Agents in Free-ranging Wildlife is designed to help wildlife authorities and others working with wildlife carry out effective surveillance programmes.

The document, which cover areas including choosing appropriate strategies, safety and biosafety protocols, and ethical and legal considerations, can be read here.  

Click here for more...
News Shorts
Restricted zone extended after more bluetongue cases

After three new cases of bluetongue virus serotype 3 were detected along the Hertfordshire and Buckinghamshire border, the restricted zone has been extended.

The zone now includes Buckinghamshire and part of Berkshire, as well as Bedfordshire, Cambridgeshire, City of Kingston upon Hull, East Riding of Yorkshire, East Sussex, Essex, Greater London, part of Hampshire, Hertfordshire, Kent, part of Leicestershire, Lincolnshire, Norfolk, part of Northamptonshire, Nottinghamshire, Suffolk, Surrey, and West Sussex.

Susceptible animals in the restricted zone should only be moved if it is essential. A specific licence is needed to move a susceptible animal from within the restricted zone to outside of the zone.

Bluetongue is a notifiable disease. Suspected cases must be reported on 03000 200 301 in England or 03003 038 268 in Wales. In Scotland, suspected cases should be reported to the local field services office. In Northern Ireland, suspected cases should be reported to the DAERA Helpline on 0300 200 7840 or by contacting the local DAERA Direct Veterinary Office.

A map of the areas where restrictions apply can be found here.