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Study reveals insights into how animals adapt between seasons
The study of sheep reveals how the brain changes in response to daylight hours to adapt to the changing conditions.

Genetic 'flip-flop' timer key to functions such as fertility, researchers conclude.

A new study led by the Universities of Edinburgh and Manchester has revealed insights into how how animals adapt between seasons.

Published in the journal Nature Communications, the study reveals how a biological switch helps animals make changes that are key to their survival, such as adjusting body temperature and growing a warm, winter coat.

The study of sheep shows how the brain changes in response to daylight hours to enable animals to adapt to the changing conditions. Researchers say that it could also help explain seasonal adaptions in other species, such as mammals, birds and reptiles.

“Fluctuations in hormones and behaviour are part of a delicate biological orchestra that is crucial to life,” explained Professor Simone Meddle, who co-led the research from the University of Edinburgh’s Roslin Institute. “Many animals depend on seasonal changes in their biology to survive and our findings are a crucial part of the puzzle to understand the underlying processes.”

Circadian rhythms – the 24 hour cycles that govern physical, mental and behavioural changes – alter during the course of a day and are influenced by genetics. Comparable rhythms also occur seasonally, but until this study it was not understood how genes play a role in the biological changes that fluctuate between summer and winter.

In the study, researchers studied the pituitary gland in sheep experiencing short or long lengths of day. They analysed brain tissue for gene activity across time, which enabled them to see how the biological processes respond to different day lengths.

The team found that one of two possible biological mechanisms is activated within the pituitary gland depending on whether the day is long or short.

When nights are long in summer, the brain generates hormones that cause a deluge of genetic activity leading to biological characteristics associated with summer. In winter, however, the switch is flipped and night time hormones are released for longer, triggering biological processes linked to this season.

The study concludes that, in the sheep brain, both processes involve a circadian gene known as BMAL2 – a gene that is found in many animals, but whose role in the seasonal clock was previously unknown.

“The genetic ‘flip-flop’ timer we have identified is key to functions such as fertility as sheep transition between winter and summer,” said Professor Andrew Loudon, who co-led the study from the University of Manchester. “We speculate that this genetic timer is likely to be fundamental to yearly changes in many species.” 

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Vets to run marathon for World Animal Protection

News Story 1
 Two recently graduated veterinary surgeons will be running the London Marathon in April to raise money for the charity World Animal Protection.

Alex Bartlett and Maeve O'Neill plan to run the race together if they are given the same start times.

Dr O'Neill said: "You're always limited in what you can do to help animals, so it is nice to raise money for a charity that helps animals around the world."

Dr Bartlett added: "I have never run a marathon before and am excited to run my first one for such a good cause!"

Both Dr Bartlett and Dr O'Neill have fundraising pages online. 

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BSAVA releases new Guide to Procedures

The British Small Animal Veterinary Association (BSAVA) has published a new edition of its Guide to Procedures for Small Animal Practice.

It has added four new procedures; cystostomy tube placement, endotracheal intubation, point-of-care ultrasound and wet-to-dry dressings.

BSAVA says that it is an essential step-by-step guide to diagnostic and therapeutic procedures performed in practice. The textbook includes new images and illustrations, as well as high-definition videos for use prior to procedures.

Nick Bexfield and Julia Riggs, editors of the new edition, said: "We have built upon the success of the previous editions by responding to the feedback received from the BSAVA readership, and hope this new guide helps to further increase the confidence and accuracy with which these procedures are performed."

Print copies are available in the BSAVA store, with a digital version in the BSAVA library.