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Major step forward in thermally-stable TB vaccines
The findings, published in Scientific Reports, were described by researchers as a big step forward.
Promising vaccine can be protected from heat damage - study

A promising TB vaccine for cattle and humans can be protected from heat damage, using a new technique developed at the University of Bath, scientists say.

The new method, called ensilication, prevents crucial vaccine components spoiling outside the fridge by ‘shrink wrapping’ the proteins in position, using layers of silica that build a ‘cage’ around the molecules.

Researchers showed that the TB antigen ag85b and a vaccine fused with the adjuvant protein Sbi, are sensitive to breakdown outside of the fridge.

They were then able to show for the first time that these vaccine components were protected from heat damage when ensilicated and kept at room temperature for long periods of time.

The findings, published in Scientific Reports, were described by researchers as a big step forward, not only in developing thermally-stable TB vaccines, but also in showing that this technique could be used for many different kinds of vaccine.

Fifty per cent of vaccines are currently discarded before use, after exposure to suboptimal temperatures. The World Health Organisation named thermostable vaccines a priority research area in its Global Vaccine Action Plan for 2011-2020.

Lead author Professor Jean van den Elsen said: “A new TB vaccine is really urgently needed to supplement or replace the existing BCG vaccine and reduce the number of TB cases and deaths – particularly as drug-resistant TB infections remain high.”

First author Ayla Wahid, added: “To make the vaccine as effective as possible it needs to be thermally-stable, or in other words not spoil outside of a fridge, which is why we’re really encouraged by these results. Cold-chain storage leads to a lot of wastage and expense which could be avoided by ensilication.”

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BEVA gives vets access to free membership for three months

News Story 1
 BEVA has announced that it is cutting membership renewal charges for the next three months in order to support all veterinary professionals during the COVID-19 pandemic.

Memberships for all existing BEVA members will be extended until 30 June 2020. Veterinary professionals who are not members of BEVA will also be able to sign up for a free membership until 30 June 2020.

BEVA president Tim Mair said: "In this extraordinary time of global crisis our profession, as with many industries, is under immense pressure. By offering free membership we are giving equine vets easy access to a wealth of supportive resources and online CPD."

To sign up please visit the BEVA website.

Image (c) BEVA. 

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BSAVA rolls out CPD resources and benefits in absence of Congress

A package of CPD resources and benefits are set to be rolled out on BSAVA's social media channels over the coming days in a bid to fill the gap left by the cancellation of BSAVA Congress.

The package includes a 10 discount voucher on all printed manuals and access to the BSAVA Library. BSAVA said that it will also be recording more than 100 hours of planned Congress lectures over the following weeks so that vets don't completely miss out on the Congress experience.

The resource, titled Congress on Demand will be ready in early May.