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Major step forward in thermally-stable TB vaccines
The findings, published in Scientific Reports, were described by researchers as a big step forward.
Promising vaccine can be protected from heat damage - study

A promising TB vaccine for cattle and humans can be protected from heat damage, using a new technique developed at the University of Bath, scientists say.

The new method, called ensilication, prevents crucial vaccine components spoiling outside the fridge by ‘shrink wrapping’ the proteins in position, using layers of silica that build a ‘cage’ around the molecules.

Researchers showed that the TB antigen ag85b and a vaccine fused with the adjuvant protein Sbi, are sensitive to breakdown outside of the fridge.

They were then able to show for the first time that these vaccine components were protected from heat damage when ensilicated and kept at room temperature for long periods of time.

The findings, published in Scientific Reports, were described by researchers as a big step forward, not only in developing thermally-stable TB vaccines, but also in showing that this technique could be used for many different kinds of vaccine.

Fifty per cent of vaccines are currently discarded before use, after exposure to suboptimal temperatures. The World Health Organisation named thermostable vaccines a priority research area in its Global Vaccine Action Plan for 2011-2020.

Lead author Professor Jean van den Elsen said: “A new TB vaccine is really urgently needed to supplement or replace the existing BCG vaccine and reduce the number of TB cases and deaths – particularly as drug-resistant TB infections remain high.”

First author Ayla Wahid, added: “To make the vaccine as effective as possible it needs to be thermally-stable, or in other words not spoil outside of a fridge, which is why we’re really encouraged by these results. Cold-chain storage leads to a lot of wastage and expense which could be avoided by ensilication.”

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COVID-19 resources for veterinary professionals

News Story 1
 RCVS Knowledge, the charity partner of the Royal College of Veterinary Surgeons (RCVS), has published a page of COVID-19 coronavirus resources for veterinary professionals across the industry.

The resource, which can be found here, includes veterinary advice, updates, research and evidence regarding the virus. The advice encompasses information to help veterinary professionals respond to questions from their clients and the BCVA's latest guidance for farm animal vets.

Veterinary professionals are urged to share the resource on social media and let RCVS Knowledge know of any additions. 

Click here for more...
News Shorts
BVA senior vice president appointed chair of FVE working group

Senior vice president of the BVA Dr Simon Doherty has been appointed as chair of the Food Safety & Sustainability working group of the Federation of Veterinarians in Europe (FVE).

Dr Doherty has 20 years' experience in farm animal and equine veterinary practice, industry and academia. He has been working as a senior lecturer at the Queen's University Belfast Institute for Global Food Security since 2018 and is a trustee of Send a Cow and the Animal Welfare Foundation.

The Food Safety & Sustainability working group will support FVE in all matters related to food safety, food security and sustainable livestock systems. It will also assist FVE in taking the most effective policies at EU level.