Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Osteosarcoma genetically similar in dogs and human children - study
Researchers found that canine OS shares many of the genomic features of human OS.

Findings could lead to better treatments

The bone cancer osteosarcoma is genetically similar in dogs and human children, according to new research.

The study, published in Communications Biology, could help in the treatment of the disease, which has not seen a significant medical breakthrough in almost 30 years.

Senior author Will Hendriks said: “While osteosarcoma (OS) is rare in children, it is all too common in many dog breeds, which makes it a prime candidate for the kind of comparative cancer biology studies that could enhance drug development for both children and our canine friends.”

In the study, researchers at Tufts University and Translational Genomics Research sequenced the genomes of 59 dogs.

They found that canine OS shares many of the genomic features of human OS, including low mutation rates, altered cellular pathways and unique genetic features of metastatic tumours.

Professor in comparative oncology Cheryl A. London said the findings "set the stage for understanding OS development in dogs and humans, and establish genomic contexts for future comparative analyses.”

Researchers also identified new features of canine OS which may also warrant further investigation, including recurrent and potentially cancer-causing mutations in two genes - SETD2 and DMD.

Osteosarcoma is the most commonly-diagnosed bone cancer in dogs but it is rare in humans.

Chemotherapy and surgery can extend survival, but some 30 per cent of pediatric OS patients die from metastatic tumours within five years. In dogs, the cancer moves much faster, with more than 90 per cent succumbing to metastatic disease within two years.

Become a member or log in to add this story to your CPD history

Regional Representatives nominations sought

News Story 1
 Seven new regional representatives are being sought by the British Veterinary Association (BVA) to speak for vets from those regions and to represent their views to BVA Council.

The opportunities are available in in the North-East, Yorkshire & Humber, East Midlands, West Midlands, London, Wales, and Northern Ireland. Representatives from all sectors of the veterinary profession are urged to apply.

BVA president Daniella Dos Santos, said: "Our regional representatives are integral to that mission and to the activities of Council - contributing to effective horizon scanning on matters of veterinary policy and providing an informed steer to BVA’s Policy Committee.” 

Click here for more...
News Shorts
Livestock Antibody Hub receives funding boost

The Pirbright Institute has received US $5.5 million from the Bill and Melinda Gates Foundation to form a Livestock Antibody Hub aimed at supporting animal and human health. The work will bring together researchers from across the UK utilise research outcomes in livestock disease and immunology.

Dr Doug Brown, chief executive of the British Society for Immunology, commented: “The UK is a world leader in veterinary immunology research, and this transformative investment from the Bill & Melinda Gates Foundation will drive the next chapter of innovation in developing new treatments and prevention options against livestock diseases".