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Gene-edited chicken cells prevent spread of avian flu
The team stopped the virus from spreading by removing a section of chicken DNA inside laboratory-grown cells.

Findings increase likelihood of producing gene-edited chickens

Scientists at the University of Edinburgh have used gene editing techniques to prevent avian influenza virus spreading in laboratory-grown chicken cells.

Researchers say the findings increase the likelihood of producing gene-edited chickens that are resistant to the disease.

The team stopped the virus from spreading by removing a section of chicken DNA inside laboratory-grown cells. The next step will be to produce chickens with the genetic change.

“This is an important advance that suggests we may be able to use gene-editing techniques to produce chickens that are resistant to bird flu,” said Dr Mike McGrew, of the University of Edinburgh’s Roslin Institute. “We haven’t produced any birds yet and we need to check if the DNA change has any other effects on the bird cells before we can take this next step.”

In the study, scientists targeted a specific molecule inside chicken cells called ANP32A. Researchers at Imperial College London found that influenza viruses hijack this molecule during an infection to help replicate themselves.

Together with scientists at the University of Edinburgh’s Roslin Institute, the researchers then used gene-editing techniques to delete the section of DNA responsible for producing ANP32A. They found that the avian flu virus was not able to grow inside cells with the genetic change.

“Avian influenza resistance in broiler production is of global significance and this research is an important step toward that goal," commented Rachel Hawken of Cobb-Vantress, which provided the PhD student funding for the project.

"It is exciting for Cobb to be a part of exploring new technologies that could be used to advance poultry breeding in the future.”

 

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World Bee Day celebrations begin

News Story 1
 Today (20 May) marks the fifth annual World Bee Day, which raises awareness of the importance of bees and pollinators to people and the planet. Observed on the anniversary of pioneering Slovenian beekeeper Anton Jana's birthday, this year's celebration is themed: 'Bee Engaged: Celebrating the diversity of bees and beekeeping systems'.

Organisations and people celebrating the day will raise awareness of the accelerated decline in pollinator diversity, and highlight the importance of sustainable beekeeping systems and a wide variety of bees. Slovenia, the initiator of World Bee Day, will be focusing on teaching young people about the significance of pollinators. 

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News Shorts
Further avian flu cases confirmed

Three cases of highly pathogenic avian influenza (HPAI) H5N1 have been confirmed in recent days, bringing the total number of cases in England to 98.

On Thursday, the APHA confirmed two cases of HPAI H5N1 near Redgrave, Mid Suffolk and Market Weston, West Suffolk. A case H5N1 was also confirmed in poultry at a premises near Southwell, Newark and Sherwood, Nottinghamshire.

Protection and surveillance zones are in place around the affected premises. Further details are available at gov.uk