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AMR gene spreads between pets at UK animal hospital
Four isolates tested positive for the gene optrA and there was evidence of transmission between animals.
Practices urged to ensure adequate cleaning to reduce transmission 

A gene that allows bacteria to become resistant to linezolid, a last resort human antibiotic, has been found in four pets at a UK veterinary hospital for the first time.

Scientists from Public Health England (PHE) said the discovery is “concerning” as transmission of this organism to owners carries the risk of spread to other bacteria, including Staphylococcus aureus, leading to hard-to-treat infections.

Linezolid is used to treat certain bacterial infections in humans, such as streptococci and MRSA, but it is not licensed for veterinary use in the UK.

Routine testing at the affected veterinary hospital revealed an Enterococcus faecalis isolate from a cat wound swab, which was referred to PHE. Scientists subsequently analysed three other E faecalis isolates from two cats and one dog from the same hospital, but different households.

Four isolates from three wound swabs and a cat rectal swab were found to be resistant to linezolid and gentamicin. All four isolates were also positive for optrA and there was evidence of transmission between animals. PHE said it is the first known report of optrA-positive enterococci isolated from UK pets.

The findings were presented at the European Congress of Clinical Microbiology & Infectious Diseases in Amsterdam (13-16 April).

Lead author Dr Katie Hopkins said veterinary practices must ensure adequate cleaning takes place to minimise transmission of resistant bacteria between companion animals and people. Standard protocols for managing colonised or infected animals should prevent transmission to veterinary staff, she added. Pet owners should also wash their hands after handling pets.

In the above case, further transmission was halted by cleaning and decontamination and there is no evidence that humans became infected.

Dr Hopkins added: “Our findings further the 'One-Health' view that antibiotic-resistant bacteria can be shared by animals and humans, although the direction of transfer is often difficult to prove.

“We currently do not know the prevalence of linezolid-resistant enterococci in companion animals and therefore a joint approach to monitoring emergence and dissemination of resistance mechanisms of public health importance is needed.”

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Veterinary Evidence Student Awards winners revealed

News Story 1
 The first winners of the RCVS Knowledge Veterinary Evidence Student Awards have been revealed.

Molly Vasanthakumar scooped first prize for her knowledge summary comparing the ecological impact of woven versus disposable drapes. She found that there is not enough evidence that disposable synthetics reduce the risk of surgical site.

Second prize went to Honoria Brown of the University of Cambridge, for her paper: ‘Can hoof wall temperature and digital pulse pressure be used as sensitive non-invasive diagnostic indicators of acute laminitis onset?’

Edinburgh’s Jacqueline Oi Ping Tong won third prize for critically appraising the evidence for whether a daily probiotic improved clinical outcomes in dogs with idiopathic diarrhoea. The papers have all achieved publication in RCVS Knowledge’s peer-reviewed journal, Veterinary Evidence.  

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Animal Welfare Foundation seeks new trustees

The Animal Welfare Foundation (AWF) seeks three new trustees to help drive the charity’s mission to improve animal welfare through veterinary science, education and debate.

Veterinary and animal welfare professionals from across the UK may apply, particularly those with experience in equine and small animal practice and research management. Trustees must attend at least two meetings a year, as well as the annual AWF Discussion Forum in London.

For more information about the role, visit www.animalwelfarefoundation.org.uk. Applications close at midnight on 13 August 2019.