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Discovery offers hope for anti-cancer therapy
Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen.

Immunoglobulin E antibodies could fight cancer in humans and dogs

Antibodies that are produced in response to allergens could offer hope for a new anti-cancer therapy in dogs and humans, scientists have said.

Immunoglobulin E (IgE) antibodies are created when the immune system overreacts to an allergen, such as pollen. However, their original purpose is to repel harmful external substances.  

A team of international scientists have now developed a ‘canine IgE’ that targets the EGFR growth factor in cancerous tumours. In-vitro studies found that, in more than 60 per cent of cases, the tumour was destroyed by IgE antibodies.

IgE antibodies build a ‘bridge’ between EGFR on cancer cells and inflammatory cells, which releases tumour necrosis factors.

The study, published in the Journal of Allergy and Clinical Immunology, offers hope for humans too, as canine and human EGFR are a 92 per cent match.

Lead author Erika Jensen-Jarolim said: "We can therefore hope that we have made an important contribution towards developing a new form of immunotherapy against cancerous tumours.

"A subsequent clinical trial will be conducted in canine patients to validate the results in an international joint initiative before moving to human trials.”

Image © M. Bernkopf/Vetmeduni Vienna

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Defra extends applications to Zoo Animals Fund

News Story 1
 Defra has extended the deadline for applications for the 100 Million Zoo Animals Fund until 26 February 2021.

Launched in June 2020, the fund provides financial support for zoos and aquariums that have experienced a drop in income caused by the coronavirus pandemic. Grants of up to 730,000 are available, which can be used to pay for essential costs and maintenance, including veterinary care, medicines, animal feed and staffing.

More information about the fund and details of how to apply can be found here

Click here for more...
News Shorts
APHA confirms eighth case of highly pathogenic avian influenza in England

The Animal & Plant Health Agency (APHA) has identified an eighth case of highly pathogenic avian influenza (HPAI) H5N8 in poultry in England.

Confirmed on Tuesday (15 December), the outbreak was found in captive birds and poultry at a premises near Willington, South Derbyshire. A 3km Protection Zone and a 10km Surveillance Zone have been placed around the infected premises to limit the risk of the disease spreading.

Further information about the outbreaks and the latest government advice can be found at gov.uk