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Gene therapy ‘can cure lameness’ - study
The research team believe this gene therapy could offer a much faster healing time.
Research may also have implications for human medicine 

A ‘promising’ gene therapy could offer faster and more effective treatment for lameness in horses, scientists say.

An international team injected DNA into the tendons and ligaments of horses that were lame as a result of injury. Within two to three weeks, the horses were able to walk and trot, and after two months, they were back to full health, galloping and competing.

The results also showed that the tissue within the limbs had fully recovered. Twelve months after treatment, the horses were completely fit, active and pain free.

Scientists used a combination of the vascular endothelial growth factor gene (VEGF164), to enhance blood vessel growth, and the bone morphogenetic protein 2 (BMP2), which is important for bone and cartilage development.

Both genes were derived from horses and cloned into a single plasmid DNA, which is biologically safe and unlikely to provoke an immune reaction from the body.

The research team believe this gene therapy could offer a much faster healing time, whilst significantly reducing relapse rates. Current medical therapies have a relapse rate of 60 per cent. Even the best regenerative medicine treatments have a 20 per cent relapse rate and take five or six months to work.

Lead author Professor Albert Rizvanov, from Kazan Federal University, said: “Advancing medicine, relieving pain and restoring function were the main aims of this study. We have shown that these are possible and within a much shorter time span than treatments available at the moment.”

In addition, scientists reported that no side effects or adverse reactions were seen in the horses who received treatment.

These findings not only have implications for veterinary medicine, they could also advance treatments for humans. Scientists say this type of therapy could be used in other injuries and situations, ranging from fertility problems to spinal cord injuries.

Dr Catrin Rutland, who led the work at University of Nottingham, said: “This pioneering study advances not only equine medicine but has real implications for how other species and humans are treated for lameness and other disorders in the future. The horses returned to full health after their injuries and did not have any adverse side effects. This is a very exciting medical innovation.”

The next step is to secure funding for a larger trial.

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Laura Muir wins gold at Commonwealth Games

News Story 1
 Veterinary surgeon and Olympic silver-medalist Laura Muir scooped the gold medal in the 1500m final Commonwealth Games on Sunday.

Winning Scotland's 12th title of the games, Muir finished in four minutes 2.75 seconds, collecting her second medal in 24 hours.

Dr Muir commented on her win: "I just thought my strength is in my kick and I just tried to trust it and hope nobody would catch me. I ran as hard as I could to the line.

"It is so nice to come here and not just get one medal but two and in such a competitive field. Those girls are fast. It means a lot." 

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Views sought on NOAH Compendium

Users of the National Office of Animal Health (NOAH) Compendium app and website are being asked to share their views on how it can be improved.

In a new survey, users are asked about some suggested future developments, such as notifications for new and updated datasheets, sharing links to datasheets, and enhanced search functionality.

It comes after NOAH ceased publication of the NOAH Compendium book as part of its sustainability and environmental commitments. The website and the app will now be the main routes to access datasheets and view any changes.