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Gene therapy ‘can cure lameness’ - study
The research team believe this gene therapy could offer a much faster healing time.
Research may also have implications for human medicine 

A ‘promising’ gene therapy could offer faster and more effective treatment for lameness in horses, scientists say.

An international team injected DNA into the tendons and ligaments of horses that were lame as a result of injury. Within two to three weeks, the horses were able to walk and trot, and after two months, they were back to full health, galloping and competing.

The results also showed that the tissue within the limbs had fully recovered. Twelve months after treatment, the horses were completely fit, active and pain free.

Scientists used a combination of the vascular endothelial growth factor gene (VEGF164), to enhance blood vessel growth, and the bone morphogenetic protein 2 (BMP2), which is important for bone and cartilage development.

Both genes were derived from horses and cloned into a single plasmid DNA, which is biologically safe and unlikely to provoke an immune reaction from the body.

The research team believe this gene therapy could offer a much faster healing time, whilst significantly reducing relapse rates. Current medical therapies have a relapse rate of 60 per cent. Even the best regenerative medicine treatments have a 20 per cent relapse rate and take five or six months to work.

Lead author Professor Albert Rizvanov, from Kazan Federal University, said: “Advancing medicine, relieving pain and restoring function were the main aims of this study. We have shown that these are possible and within a much shorter time span than treatments available at the moment.”

In addition, scientists reported that no side effects or adverse reactions were seen in the horses who received treatment.

These findings not only have implications for veterinary medicine, they could also advance treatments for humans. Scientists say this type of therapy could be used in other injuries and situations, ranging from fertility problems to spinal cord injuries.

Dr Catrin Rutland, who led the work at University of Nottingham, said: “This pioneering study advances not only equine medicine but has real implications for how other species and humans are treated for lameness and other disorders in the future. The horses returned to full health after their injuries and did not have any adverse side effects. This is a very exciting medical innovation.”

The next step is to secure funding for a larger trial.

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Webinar to focus on equine worm control

News Story 1
 Vets, veterinary nurses and RAMAs are being invited to join a free CPD webinar on late winter and early spring equine worm control.

Hosted by Zoetis vet Dr Wendy Talbot, the webinar aims to help prescribers understand which parasites are of most concern at this time of year. It will also cover how to assess parasite risk, selecting a suitable wormer and spring wormer plans, concluding with a Q&A session.

The webinar takes place on Thursday, 18 March at 10 am and will be repeated at 7 pm for those unable to listen during the day. To book the 10 am webinar, click here, and to register for the 7 pm webinar, click here

Click here for more...
News Shorts
Avian influenza confirmed in Lancashire

A case of highly pathogenic (HPAI H5N8) avian influenza has been confirmed in two captive peregrine falcons on a non-commercial, non-poultry premises near Skelmersdale, West Lancashire.

Following a risk assessment, APHA has declared that no disease control zones have been put in place surrounding this non-commercial, non-poultry premises.

Eighteen cases of HPAI H5N8 have now been identified in poultry and other captive birds in England. A housing order for poultry and captive birds introduced by Defra to control the spread of the disease expired on 31 March, although bird keepers in England are still required by law to comply with biosecurity measures.

For more information, please click here.