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Study reveals how Lyme disease spreads through the body
Lyme disease bacteria
Lyme disease bacteria (Borrelia burgdorferi) spreads through the body by clinging to the lining of blood vessels.

Cell-imaging approach offers new insights

Research by the University of Toronto has revealed how Lyme disease bacteria spreads through the body.

Published in the journal Cell Reports, the study found that a special adhesion protein called BBK32 helps Lyme disease bacteria (Borrelia burgdorferi) cling onto and move along the inside lining of blood vessels.  

"It's likely that this property helps the bacteria get to sites where they might be able to persist longer, and this property might therefore make it harder to treat infections caused by these bacteria," explains first author Rhodaba Ebady.

In the study, the team developed a live-imaging-cell based system that provides both molecular and biomechanical insights into how bacteria travels throughout the body.

Using genetically modified strains of Borrelia burgdorferi, the team watched through a microscope as the bacteria - marked with fluorescent green protein - moved across cells in real time.

Their findings suggest that drugs targeting BBK32 could help to prevent or slow down the spread of Lyme disease bacteria to joints, the heart and nervous system.

This would eliminate or reduce the severity of symptoms like heart inflammation, arthritis, facial paralysis and nerve pain, the researchers say.

Furthermore, because BBK32-like proteins are produced by pathogens like Staphylococcus aureus and Streptococcus pyogenes, the researchers believe their findings may also be relevant to other serious conditions, like pneumonia and inflammation affecting the heart.

Looking ahead, the team hope to identify endothelial receptors that BBK32 interact with, assess the biomechanical role of bacterial flagella in vascular interactions, and try to determine how bacteria target specific endothelia associated with different tissues.

More broadly, the team hope their cell-imaging approach could be used to study how other pathogens spread throughout the body.

Image (C) Jamice Haney Carr, Claudia Molins, USCDCP 

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Free CPD announced for BVNA members

News Story 1
 Zoetis is to present a CPD event for free to members of the British Veterinary Nursing Association (BVNA).

Led by veterinary consultant Ruth Moxon, the one-hour online session is designed to help veterinary nurses discuss parasiticide options with clients. It will advise on structuring recommendations, factors for product choice and moving away from 'selling'.

'How do you recommend parasite treatments to your clients?' will be presented on Tuesday, 20 May at 7.30pm. It is free for BVNA members, with £15.00 tickets for non-members.

Veterinary nurses can email cpd@bvna.co.uk to book their place. 

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DAERA to reduce BVD 'grace period'

DAERA has reminded herd keepers of an upcoming reduction to the 'grace period' to avoid BVD herd restrictions.

From 1 May 2025, herd keepers will have seven days to cull any BVD positive or inconclusive animals to avoid restrictions being applied to their herd.

It follows legislation introduced on 1 February, as DAERA introduces herd movement restrictions through a phased approach. Herd keepers originally had 28 days to cull BVD positive or inconclusive animals.

DAERA says that, providing herd keepers use the seven-day grace period, no herds should be restricted within the first year of these measures.

Additional measures, which will target herds with animals over 30 days old that haven't been tested for BVD, will be introduced from 1 June 2025.

More information is available on the DAERA website.