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Study reveals how Lyme disease spreads through the body
Lyme disease bacteria
Lyme disease bacteria (Borrelia burgdorferi) spreads through the body by clinging to the lining of blood vessels.

Cell-imaging approach offers new insights

Research by the University of Toronto has revealed how Lyme disease bacteria spreads through the body.

Published in the journal Cell Reports, the study found that a special adhesion protein called BBK32 helps Lyme disease bacteria (Borrelia burgdorferi) cling onto and move along the inside lining of blood vessels.  

"It's likely that this property helps the bacteria get to sites where they might be able to persist longer, and this property might therefore make it harder to treat infections caused by these bacteria," explains first author Rhodaba Ebady.

In the study, the team developed a live-imaging-cell based system that provides both molecular and biomechanical insights into how bacteria travels throughout the body.

Using genetically modified strains of Borrelia burgdorferi, the team watched through a microscope as the bacteria - marked with fluorescent green protein - moved across cells in real time.

Their findings suggest that drugs targeting BBK32 could help to prevent or slow down the spread of Lyme disease bacteria to joints, the heart and nervous system.

This would eliminate or reduce the severity of symptoms like heart inflammation, arthritis, facial paralysis and nerve pain, the researchers say.

Furthermore, because BBK32-like proteins are produced by pathogens like Staphylococcus aureus and Streptococcus pyogenes, the researchers believe their findings may also be relevant to other serious conditions, like pneumonia and inflammation affecting the heart.

Looking ahead, the team hope to identify endothelial receptors that BBK32 interact with, assess the biomechanical role of bacterial flagella in vascular interactions, and try to determine how bacteria target specific endothelia associated with different tissues.

More broadly, the team hope their cell-imaging approach could be used to study how other pathogens spread throughout the body.

Image (C) Jamice Haney Carr, Claudia Molins, USCDCP 

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Prof Joanne Webster elected as Fellow of the Royal Society

News Story 1
 Joanne Webster, a professor of parasitic diseases at the RVC, has been elected as a Fellow of the Royal Society (FRS).

An infectious disease expert, Prof Webster is known for promoting a One Health approach to disease control.

She completed her doctoral research in zoonotic disease and parasite-host interactions, and has since earned widespread recognition for contributions to parasitology and global health.

Prof Webster said: "I am truly honoured, and somewhat stunned, to be recognised alongside such an exceptional group of scientists." 

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Germany FMD import restrictions eased

The UK government has lifted the import restrictions placed on FMD-susceptible commodities from Germany.

The decision comes after the country was recognised as foot-and-mouth disease free without vaccination on 14 May.

Imports of FMD-susceptible animals and their by-products from Germany were originally banned, after the country reported a case of FMD near Brandenburg in January. In March, the UK government permitted imports from outside of the outbreak zone.

Germany will now be able to import FMD-susceptible animals and their by-products into the UK, providing they meet other import conditions.

The decision follows rigorous technical assessment of measures in Germany. Defra says it will not hesitate respond to FMD outbreaks.