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Study reveals how Lyme disease spreads through the body
Lyme disease bacteria
Lyme disease bacteria (Borrelia burgdorferi) spreads through the body by clinging to the lining of blood vessels.

Cell-imaging approach offers new insights

Research by the University of Toronto has revealed how Lyme disease bacteria spreads through the body.

Published in the journal Cell Reports, the study found that a special adhesion protein called BBK32 helps Lyme disease bacteria (Borrelia burgdorferi) cling onto and move along the inside lining of blood vessels.  

"It's likely that this property helps the bacteria get to sites where they might be able to persist longer, and this property might therefore make it harder to treat infections caused by these bacteria," explains first author Rhodaba Ebady.

In the study, the team developed a live-imaging-cell based system that provides both molecular and biomechanical insights into how bacteria travels throughout the body.

Using genetically modified strains of Borrelia burgdorferi, the team watched through a microscope as the bacteria - marked with fluorescent green protein - moved across cells in real time.

Their findings suggest that drugs targeting BBK32 could help to prevent or slow down the spread of Lyme disease bacteria to joints, the heart and nervous system.

This would eliminate or reduce the severity of symptoms like heart inflammation, arthritis, facial paralysis and nerve pain, the researchers say.

Furthermore, because BBK32-like proteins are produced by pathogens like Staphylococcus aureus and Streptococcus pyogenes, the researchers believe their findings may also be relevant to other serious conditions, like pneumonia and inflammation affecting the heart.

Looking ahead, the team hope to identify endothelial receptors that BBK32 interact with, assess the biomechanical role of bacterial flagella in vascular interactions, and try to determine how bacteria target specific endothelia associated with different tissues.

More broadly, the team hope their cell-imaging approach could be used to study how other pathogens spread throughout the body.

Image (C) Jamice Haney Carr, Claudia Molins, USCDCP 

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Vetlife nominated for campaign award

News Story 1
 Vetlife has been shortlisted for the Association of Charity Organisations (ACO) Campaign of the Year Award 2024.

The nomination recognises its campaigning to raise awareness of neurodiversity within the profession and produce resources for individuals and workplaces. Vetlife's campaign has included talks, lived experience blogs, and an awareness video.

Kirstie Pickles, Vetlife trustee and project lead, said: "I am thrilled and delighted that the Vetlife neurodiversity awareness campaign has been shortlisted for the ACO Campaign of the Year Award 2024"

The winner will be announced 12 September 2024. 

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Northern Ireland chief vet warns of bluetongue risk

Following the detection of bluetongue virus serotype 3 (BTV-3) in England, Northern Ireland's chief veterinary officer has urged farmers to remain vigilant and source animals responsibly.

Brian Dooher said: "This confirmation in England is a stark reminder of the threat bluetongue presents to Northern Ireland.Whilst this finding in Norfolk is disappointing it is not unexpected giving the rising level of disease across several countries in Europe. Bluetongue does not affect human health or food safety, however an incursion to Northern Ireland would have a significant impact on livestock and the rural economy.

"I would like to remind all farmers of the importance of sourcing animals responsibly and ask that they maintain vigilance for signs of the disease reporting any suspicions to DAERA immediately."

Suspected cases of BTV-3 in Northern Ireland should be reported to the DAERA Helpline on 0300 200 7840 or by contacting the local DAERA Direct Veterinary Office.