Your data on MRCVSonline
The nature of the services provided by Vision Media means that we might obtain certain information about you.
Please read our Data Protection and Privacy Policy for details.

In addition, (with your consent) some parts of our website may store a 'cookie' in your browser for the purposes of
functionality or performance monitoring.
Click here to manage your settings.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Research finds new immune-related genes in horses
The discovery contributes to our knowledge of how MHC genes affect horses' immune systems.

The discovery highlights diversity in immune system genes.

The University of Edinburgh’s Royal (Dick) School of Veterinary Studies have identified a range of newly uncovered gene sequences in horses’ immune systems.

The discovery of these new gene sequences reveals a larger variety of equine immune genes than were previously known, providing a stronger insight into the genetic makeup of horses and how they fight disease.

The researchers collaborated with scientists in England, Iceland and Norway to conduct analysis of genetic data from 168 horses, across three European breeds. The group used genetic sequencing technology to examine immune genes, known as Major Histocompatibility Complex (MHC), in Thoroughbred, Icelandic and Norwegian Fjords.

The analysis revealed a diversity in the immune systems’ genes when compared with horse populations which have evolved separately.

These gene sets come in two main types: MHCI and MHCII. Each type contains a complex arrangement of combinations which varies significantly per individual, supporting the immune system with recognising threats.

The analysis discovered 152 sequences of MHCI genes, which are responsible for monitoring infections within cells. It also found 117 new sequences of MHCII, which monitor for infections in surrounding cells.

There was a limited overlap in these gene types across the three horse breeds, which may mean that there is even greater MHC diversity in the global horse population.

Discovering these new genes may contribute to our knowledge of how MHC genes affect horses’ immune systems, as well as wider implications for clinical treatments.

It will also help with our understanding of equine health and disease, and inform breeding practices.

Dr Tim Connelley, research fellow at University of Edinburgh’s Roslin Institute, said: “We found a wide range of MHC genes and patterns of gene expression, allowing us to get a glimpse of how this set of genes may function in horses.

“These results could prove useful for vaccine development and novel cell-based therapies that are becoming more adopted in equine medicine."

The full study is published in the journal Cell.

Image © Shutterstock

Become a member or log in to add this story to your CPD history

Survey launched to investigate EHV

News Story 1
 Zoetis has launched a new survey to identify management techniques for Equine Herpes Virus (EHV).

EHV is a contagious, airborne virus that can cause respiratory problems and severe diseases in horses and ponies. It spreads among horses over short distances, direct contact and through shared equipment.

The survey will explore current knowledge and management practices with EHV in the UK. It is quick to complete and participants could win one of 10 equine first aid kits.

Complete the survey here

Click here for more...
News Shorts
WSAVA launches pet travel guidance factsheet

A new pet travel guidance factsheet for veterinary professionals and caregivers has been developed by the WSAVA in collaboration with the World Veterinary Association.

The Dog and Cat Welfare During Transport factsheet provides step-by-step guidance for all stages of a journey, from pre-travel checklists to post-travel care.

Brachycephalic breeds or animals prone to travel-related anxiety are given special focus in this guide, which also provides links to IATA container regulation and WSAVA vaccination guidelines.