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Genome sequencing reveals insights into atopic dermatitis
Researchers identified connections between atopic dermatitis and severla regions of the genome.
Links found between canine and human risk factors.

A study from Uppsala University's dog genetics group has found connections between atopic dermatitis (eczema) in dogs and regions of the genome.

The researchers identified candidate genes with potential relevance to how canine atopic dermatitis develops, and found links with atopic eczema in humans. 

Ordinary blood samples from dogs were used in genome sequencing, and new gene mapping methods provided a better understanding of the complex genetics involved in canine atopic dermatitis, identifying risk factors.

Katarina Tengvall, first author of the study, said: “The new methods make it possible to find new risk factors that have become common in the specific breed, perhaps because of the selection for other characteristics.

“The candidate genes identified here are important for both the nature of the skin barrier and the immune defence, as expected in atopic eczema.”

While the study showed several correspondences with genes associated with atopic dermatitis in humans, the most powerful genetic risk factor in humans - the genetic region containing filaggrin gene - is also a risk factor in dogs.

Senior author of the study Professor Kerstin Lindblad-Toh explained: “This highlights the value of canine studies of genetic diseases that also affect humans. 

“A better understanding of the disease mechanisms may ultimately lead to better therapies for dog and human alike.” 

Published in Communications Biology, the full study is available to read on the journal's webpage.

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Defra shares new Sanitary and Phytosanitary guidance

News Story 1
 Defra has published guidance for the vet sector ahead of a proposed UK-EU Sanitary and Phytosanitary agreement.

The agreement, which will change the movement and trade of animals and related products, could see reductions in checks, paperwork and certification. As well as describing regulatory developments, the advice highlights the importance of animal ID, registration and traceability in disease control and other compliance arrangements.

The guidance can be found here. More detail is expected as negotiations progress. 

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News Shorts
Lords Committee opens Pet Parasite Medication inquiry

The House of Lords Environment and Climate Change Committee will launch its inquiry into Pet Parasite Medication (PPM) on Wednesday (3 June).

Focusing on treatments containing fipronil and imidacloprid, the inquiry will seek to understand distribution pathways and the impacts of PPM use and non-use on biodiversity and human health. It will also cover current regulation, monitoring, and the potential implications for pets and their owners.

The committee will hear evidence from environmental non-governmental organisations and research institutes. The public can follow the proceedings live on Parliament TV or in person in the Palace of Westminster.