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New insights into retention of FMDV
The outcomes of the study could benefit farmers of African buffalo, whose herds can harbour the disease for five years or more.
Foot-and-Mouth Disease study explores persistent infection.

A new study has revealed detailed insights into how the Foot-and-Mouth Disease Virus (FMDV) causes persistent infection in livestock.

A team comprised of researchers from the Roslin Institute and the Pirbright Institute explored how FMDV interacts with immune cells, in order to inform the development of a future long-lasting vaccine.

Using mice in the study, the scientists found that FMDV binds to follicular dendritic cells, found in lymphoid tissues in the immune system, such as in the spleen.

The Pirbright Institute's Professor Bryan Charleston explained: “This research helps to bridge the knowledge gap of how the immune system deals with FMDV infection in large animals.

“Our extensive work in African buffalo, a natural host of the disease, allowed us to predict why and how persistence may occur and then test this theory in a small animal model.”

Follicular dendritic cells, which FMDV binds to, behave similarly to spider webs, trapping foreign particles and certain viruses within them for significant periods of time, in order for the other cells in the immune system to make immune responses.

This retention of the virus within the follicular dendritic cells is what the researchers believe may assist the virus in persisting in livestock, allowing them to become carriers and risking the health of other susceptible livestock.

Professor Neil Mabbott, of the Roslin Institute, commented on the value of the research for informing future vaccine development: “Our research has uncovered a key biological process by which the virus for Foot-and-Mouth Disease is able to remain in the immune systems of animals such as African buffalo.

“This could inform efforts to develop improved vaccines which, unlike current vaccines, provide longer term protection to safeguard livestock.”

The study is published in PLOS Pathogens.

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Defra shares new Sanitary and Phytosanitary guidance

News Story 1
 Defra has published guidance for the vet sector ahead of a proposed UK-EU Sanitary and Phytosanitary agreement.

The agreement, which will change the movement and trade of animals and related products, could see reductions in checks, paperwork and certification. As well as describing regulatory developments, the advice highlights the importance of animal ID, registration and traceability in disease control and other compliance arrangements.

The guidance can be found here. More detail is expected as negotiations progress. 

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News Shorts
Lords Committee opens Pet Parasite Medication inquiry

The House of Lords Environment and Climate Change Committee will launch its inquiry into Pet Parasite Medication (PPM) on Wednesday (3 June).

Focusing on treatments containing fipronil and imidacloprid, the inquiry will seek to understand distribution pathways and the impacts of PPM use and non-use on biodiversity and human health. It will also cover current regulation, monitoring, and the potential implications for pets and their owners.

The committee will hear evidence from environmental non-governmental organisations and research institutes. The public can follow the proceedings live on Parliament TV or in person in the Palace of Westminster.