Your data on MRCVSonline
The nature of the services provided by Vision Media means that we might obtain certain information about you.
Please read our Data Protection and Privacy Policy for details.

In addition, (with your consent) some parts of our website may store a 'cookie' in your browser for the purposes of
functionality or performance monitoring.
Click here to manage your settings.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Study reveals insights into how FMDV interacts with immune system
The study revealed that the interaction between FMDV and the immune system helps the virus to persist in animals such as African buffalo.

Findings could provide clues about how to increase vaccine protection longevity.

Researchers at The Pirbright Institute have revealed how the foot-and-mouth-disease virus (FMDV) interacts with lymphoid tissues to create vaccines that give long-lasting immunity to livestock.

The study found that the interaction between FMDV and the immune system helps the virus to persist in animals such as African buffalo, enabling them to become carriers of the disease and, therefore, pose a risk to other susceptible livestock.

Given that current vaccinations only give short-term protection, scientists believe that better knowledge of immunity to FMDV might lead to the development of longer-lasting vaccines that would benefit those farmers whose livelihoods depend on them.

In the study, scientists used a mouse model to investigate how FMDV persists in African buffalo and discovered that FMDV binds to cells in the immune system called follicular dendritic cells.
Follicular dendritic cells are found in lymphoid tissues, part of the adaptive immune response, and allow the immune system to mount a specific response.

The study also found that FMDV binds to a receptor known as CR2/CR1, which is essential for trapping and retaining the virus that, in turn, leads to a better and longer-lived immune response. 

Researchers also revealed which lymphoid tissues were important in FMDV infection and correlated to researchers’ predictions on the origins of persistence in African buffalo. 

Professor Bryan Charleston, director of The Pirbright Institute and head of the Viral Immunology Group, said: “This research helps to bridge the knowledge gap of how the immune system deals with FMDV infection in large animals. Our extensive work in African buffalo, a natural host of the disease, allowed us to predict why and how persistence may occur and then test this theory in a small animal model. 

"This has given us new insights into the immune responses to FMDV and could provide clues about how to increase vaccine protection longevity.” 


Become a member or log in to add this story to your CPD history

Avian flu outbreak at RSPB Minsmere

News Story 1
 RSPB Minsmere nature reserve in Suffolk has confirmed an outbreak of highly pathogenic avian influenza on its site. The coastal nature reserve has seen an increase in dead birds recently, and has said that it is 'extremely concerned' about the potential impacts on bird populations, with 2021 and 2022 seeing the largest ever outbreak in the UK.

In a statement, RSPB said: "We appreciate that it is distressing, for both visitors and staff, to see dead or dying birds at our site but we ask that if visitors see any dead or unwell birds, they do not touch or go near them and that they report it to us at our Visitor Centre during its opening hours, or by emailing us on outside of these times."  

Click here for more...
News Shorts
Moredun Foundation Award opens for applications

The 2022-2023 Moredun Foundation Award (MFA) is now open for members, with up to £2,000 available for successful applicants.

The MFA honours the contribution that education, teamwork, life experience, and travel have made to the understanding of cattle health and welfare. Through its charitable endeavours, Moredun offers its members the opportunity to pursue projects that support personal development.

The prize is open to a wide range of project applications, including those that include producing educational tools, conducting a small research project, or studying farming methods in other nations. For more information and to apply, visit