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World-first study into blood pressure and renal function in cats
“This study has shown us, as proof of concept, that large scale genomic studies will be important for understanding the pathogenesis of such complex disease conditions" - Rosanne Jepson, RVC.
Findings may reveal insights into the development of chronic kidney disease and hypertension.

A team from the Royal Veterinary College (RVC) has carried out a world-first genome study evaluating renal function and blood pressure traits in domestic cats.

The study, published in the journal Scientific Reports, could reveal insights into new and important information about the development of chronic kidney disease (CKD) and hypertension (HTN). 

In the study, researchers examined the archives of some 1,022 domestic cats seen at both the RVC’s Beaumont Sainsbury Animal Hospital and Bow PDSA Pet Hospital since 1992. The team were specificially looking for genetic associations with CKD and HTN using a genome-wide association study (GWAS) approach.

The GWAS approach used a special feline array to characterise more than 63,000 genetic differences across the feline genome. Researchers looked at the impact of different genes on these complex disease traits, which might lead to new treatment options because the pathways and proteins regulated by these genes can reveal novel disease processes. 

The study also highlighted the potential of using this approach to investigate complex disease conditions in the future. 

Historically, the study method has been used for rarer and breed-specific conditions where single genetic mutations occur. However, the findings show it could be used to generate novel information about common and complex diseases that are likely to be the consequence of genetic, lifestyle and environmental risks. 

Rosanne Jepson, principal author of the paper and associate professor in small animal internal medicine at the RVC, said: “This was an exciting opportunity to explore potential genetic influences on the development of chronic kidney disease and systemic hypertension in cats, collaborating with key opinion leaders who work and have published extensively in this field in human medicine.

“These conditions are complex - meaning that there are many factors relating to genetics, lifestyle and environment that cumulatively determine whether an individual may develop either CKD or hypertension in their lifetime.

“This study has shown us, as proof of concept, that large scale genomic studies will be important for understanding the pathogenesis of such complex disease conditions and may help to identify novel pathways as targets for diagnosis and management in the future.”

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Webinar to explore history of KC breed registers

News Story 1
 A free webinar exploring the development of the Kennel Club's registration system and the evolution of closed breed registers has been announced.

Hosted by Dr Alison Skipper, veterinary and research advisor at the Kennel Club, the webinar will delve into the development of the registry and how the changing landscape of scientific knowledge has shaped breeding practices. It will also look at what this means for the future of pedigree dogs.

The session will culminate with a look at The Kennel Club's ongoing and future engagement in this area, with a chance for attendees to put forward their thoughts and questions for discussion.

This event takes place on Microsoft Teams on Tuesday, 10 June at 7pm. To learn more, visit events.teams.microsoft.com  

Click here for more...
News Shorts
UK's BSE risk status downgraded

The WOAH has downgraded the UK's international risk status for BSE to 'negligible'.

Defra says that the UK's improved risk status recognises the reputation for having the highest standards for biosecurity. It adds that it demonstrates decades of rigorous animal control.

Outbreaks of Bovine Spongiform Encephalopathy, also known as mad cow disease, have previously resulted in bans on Britain's beef exports.

The UK's new status could lead to expanded trade and better confidence in British beef.

Christine Middlemiss, the UK's chief veterinary officer, said: "WOAH's recognition of the UK as negligible risk for BSE is a significant milestone and is a testament to the UK's strong biosecurity measures and the hard work and vigilance of farmers and livestock keepers across the country who have all played their part in managing the spread of this disease.