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Stem cell approach 'more ethical' in pig infection study
"This novel technique could help improve understanding of how infectious agents interact with the immune system of farmed animals" - Dr Stephen Meek.
Researchers at The Roslin Institute have explored the technique to produce unlimited macrophages.

New research by the University of Edinburgh's Roslin Institute has suggested that a stem cell approach is more affordable, practical and ethical than standard approaches for research into pig infections.

Using immune cells produced from stem cells will allow investigations access to an unlimited amount of macrophages, a type of immune cell, which can easily be manipulated and infected by viruses and bacteria for study.

In reducing the necessity of animals in research, and replacing the conventional procedure using macrophages extracted from slaughtered animals, researchers say that the stem cell approach is more cost-effective.

The stem cell approach could be used to produce virus for the development of live vaccines against diseases such as African swine fever.

Dr Tom Burdon, senior research fellow at the University of Edinburgh, said: “Macrophages are the first line of defence against infection, but in some cases pathogens target these cells and destroy them.

“It is not yet understood how that happens. We found that viruses replicated efficiently in macrophages derived from stem cells, showing that these cells are a great approach to learn about interactions between pig genetics and the biology of viruses or other pathogens.”

Dr Stephen Meek added: “This novel technique could help improve understanding of how infectious agents interact with the immune system of farmed animals, which ultimately can contribute to prevent disease spread and pandemics, improve animal welfare, and reduce the use of animals in research.”

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Defra shares new Sanitary and Phytosanitary guidance

News Story 1
 Defra has published guidance for the vet sector ahead of a proposed UK-EU Sanitary and Phytosanitary agreement.

The agreement, which will change the movement and trade of animals and related products, could see reductions in checks, paperwork and certification. As well as describing regulatory developments, the advice highlights the importance of animal ID, registration and traceability in disease control and other compliance arrangements.

The guidance can be found here. More detail is expected as negotiations progress. 

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News Shorts
Lords Committee opens Pet Parasite Medication inquiry

The House of Lords Environment and Climate Change Committee will launch its inquiry into Pet Parasite Medication (PPM) on Wednesday (3 June).

Focusing on treatments containing fipronil and imidacloprid, the inquiry will seek to understand distribution pathways and the impacts of PPM use and non-use on biodiversity and human health. It will also cover current regulation, monitoring, and the potential implications for pets and their owners.

The committee will hear evidence from environmental non-governmental organisations and research institutes. The public can follow the proceedings live on Parliament TV or in person in the Palace of Westminster.