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First case of Fragile Foal Syndrome found in thoroughbred horse
"While clearly a distressing condition for affected foals and their owners, the good news is that this lethal syndrome can be avoided with testing and careful mating selection" - Jessica Roach, PhD Student at the RVC.

The disorder was previously thought to affect only warmblood horses

A new study has discovered the first case of Fragile Foal Syndrome (FFS) in a thoroughbred horse, a condition previously found only in warmblood horses.

The collaborative study was carried out by the Royal Veterinary College (RVC), the University of California Davis Veterinary Genetics Laboratory (VGL) and Rossdales Laboratories, Newmarket. 

FFS is a connective tissue defect caused by a change in DNA within the procollagen-lysine, 2-oxoglutarate 5-dioxygenase1 (PLOD1) gene. It causes extensive skin lesions and musculoskeletal abnormalities, and the affected foals are aborted, stillborn or euthanised soon after birth owing to their condition.

As a autosomal recessive disorder, foals are affected if they have two copies of the mutation, so genetic testing is important for informing breeding decisions. This discovery is therefore particularly significant in highlighting the necessity of testing thoroughbred horses before breeding. 

PhD student at the RVC, Jessica Roach, said: “Pregnancy loss, stillbirth and neonatal death remain an important source of reproductive losses for horse breeders worldwide.

"Over the course of my PhD we have collated a large biobank of tissue and data from late term pregnancy losses through the generous co-operation of UK and Ireland TB stud farms and Rossdales Laboratories, Newmarket. 

“This has allowed us to explore the risk factors and pathology of many different causes of abortion and stillbirth. The collaboration with UC Davis and Lexi Grillos provided a fantastic opportunity to explore Fragile Foal Syndrome in our TB population and identify the first TB affected individual. 

“Whilst clearly a distressing condition for affected foals and their owners, the good news is that this lethal syndrome can be avoided with testing and careful mating selection.”

The study is published in Equine Veterinary Journal, and is available online at beva.onlinelibrary.wiley.com.

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Webinar to explore history of KC breed registers

News Story 1
 A free webinar exploring the development of the Kennel Club's registration system and the evolution of closed breed registers has been announced.

Hosted by Dr Alison Skipper, veterinary and research advisor at the Kennel Club, the webinar will delve into the development of the registry and how the changing landscape of scientific knowledge has shaped breeding practices. It will also look at what this means for the future of pedigree dogs.

The session will culminate with a look at The Kennel Club's ongoing and future engagement in this area, with a chance for attendees to put forward their thoughts and questions for discussion.

This event takes place on Microsoft Teams on Tuesday, 10 June at 7pm. To learn more, visit events.teams.microsoft.com  

Click here for more...
News Shorts
UK's BSE risk status downgraded

The WOAH has downgraded the UK's international risk status for BSE to 'negligible'.

Defra says that the UK's improved risk status recognises the reputation for having the highest standards for biosecurity. It adds that it demonstrates decades of rigorous animal control.

Outbreaks of Bovine Spongiform Encephalopathy, also known as mad cow disease, have previously resulted in bans on Britain's beef exports.

The UK's new status could lead to expanded trade and better confidence in British beef.

Christine Middlemiss, the UK's chief veterinary officer, said: "WOAH's recognition of the UK as negligible risk for BSE is a significant milestone and is a testament to the UK's strong biosecurity measures and the hard work and vigilance of farmers and livestock keepers across the country who have all played their part in managing the spread of this disease.