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Study offers hope for equine pregnancy loss
Dr Mandi de Mestre, a reader in reproductive immunology at the RVC.

Findings will allow researchers to develop new diagnostic tests.

One of the most common causes of equine pregnancy loss has been highlighted in a pioneering study led by researchers at the RVC.

The study, published in the journal Scientific Reports, identifies that a chromosomal defect is a key reason why a significant number of equine pregnancies fail within the first two months of development.

Researchers say the discovery could lead to the development of new diagnostic tests, offering hope to the thousands of owners of breeding mares that suffer this condition.

“Early pregnancy loss remains a very frustrating condition for clinicians to treat as the underlying cause is unknown in around 80 per cent of cases,” commented Dr Mandi de Mestre, a reader in reproductive immunology at the RVC.

“A diagnostic test would allow them to make informed decisions on treatment strategies and to advise on whether they should invest in further attempts to breed their mare benefiting both horses and their breeders alike in the future.”

Because the underlying cause behind equine pregnancy loss is often unknown, it is notoriously difficult for veterinary surgeons to manage. In this study, researchers determined 'aneuploid pregnancies' as the major factor for the condition, similar to Down’s Syndrome screened for in human pregnancy

Researchers collaborated with seven different veterinary practices to gain access to samples from across the UK and Ireland and found that around 20 per cent of the pregnancies lost were aneuploid.  To confirm the results, RVC PhD student Charlotte Shilton applied three different genetic approaches.

Scientists are now investigating the underlying cause of these aneuploid pregnancies, with early data suggesting it is most commonly introduced via the egg or sperm. Until now, chromosomal defects such as aneuploidy have only been reported as rare in young horses with developmental disorders.

Researchers say the study shows why the condition is so rare in horses and highlights the need to reconsider this condition both in pregnancy loss but also for early developmental disorders. 

Image (C) RVC.

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Practices urged to audit neutering data

News Story 1
 RCVS Knowledge has called on vet practices to audit their post-operative neutering outcomes.

It follows the release of the 2024 NASAN benchmarking report, which collates data from neutering procedures performed on dogs, cats and rabbits.

The benchmarking report enables practices in the UK and Ireland to compare their post-operative outcomes to the national average. This includes the rate of patients lost to follow-up, which in 2024 increased to 23 per cent.

Anyone from the practice can submit the data using a free template. The deadline for next report is February 2026.

Visit the RCVS Knowledge website to complete an audit. 

Click here for more...
News Shorts
New guidance for antibiotic use in rabbits

New best practice guidance on the responsible use of antibiotics in rabbits has been published by the BSAVA in collaboration with the Rabbit Welfare Association & Fund (RWA&F).

The guidance is free and has been produced to help veterinary practitioners select the most appropriate antibiotic for rabbits. It covers active substance, dose and route of administration all of which are crucial factors when treating rabbits owing to the risk of enterotoxaemia.

For more information and to access the guide, visit the BSAVALibrary.