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Pirbright Institute begins testing coronavirus vaccines on animals
The pig immune system is closely related to humans.

Scientists join global battle to help control the pandemic

Scientists at The Pirbright Institute have begun testing new coronavirus vaccines for their ability to protect against SARS-CoV-2, the strain responsible for the COVID-19 coronavirus pandemic.

The work, which is being carried out in collaboration with the University of Oxford and Public Health England (PHE), will test new vaccines for their ability to induce protective antibodies against SARS-C0V-2.

Among them includes a chimpanzee adenovirus vaccine vector (ChAdOx1), which is soon to enter human phase I clinical trials and has been used to create vaccines for diseases like Ebola and Middle Eastern respiratory syndrome (MERS).

Each vaccine candidate used in the trial will contain the spike protein from SARS-CoV-2, the protein against which protective antibodies are generated in infected patients. The vaccines will be administered to pigs, and the team will assess whether the antibodies can block SARS-CoV-2 from infecting cells.

The pig immune system is closely related to humans, so a good response to a vaccine in the pigs will help researchers predict the success of vaccines for use in humans. Scientists will also assess the safety of the new vaccines and monitor any adverse effects in the pigs.

Pirbright director, Professor Bryan Charleston, explained: “The ChAdOx1 vector vaccine developed by Oxford will be used in this SARS-CoV-2 vaccine research as it can generate a strong immune response with just a single dose.

"The vaccine vector is non-replicating which means it cannot cause ongoing infection in an individual, making it safer to use for those with underlying health conditions like diabetes. This approach has been used in other vaccines and we are hopeful that this research will enable this vaccine to move into the next stage of human testing."

Dr Toby Tuthill, head of the virus programme at Pirbright, added: “This work is a fantastic collaboration between world-leading medical and veterinary scientists in immunology, virology and molecular biology.

“It will provide an evaluation of new SARS-CoV-2 vaccines in a relevant model and will also generate a panel of antibody-based tools which will help us understand virus structure and how it stimulates the immune response. These antibodies could also be developed as additional novel therapeutics to treat COVID-19.”

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Practices urged to audit neutering data

News Story 1
 RCVS Knowledge has called on vet practices to audit their post-operative neutering outcomes.

It follows the release of the 2024 NASAN benchmarking report, which collates data from neutering procedures performed on dogs, cats and rabbits.

The benchmarking report enables practices in the UK and Ireland to compare their post-operative outcomes to the national average. This includes the rate of patients lost to follow-up, which in 2024 increased to 23 per cent.

Anyone from the practice can submit the data using a free template. The deadline for next report is February 2026.

Visit the RCVS Knowledge website to complete an audit. 

Click here for more...
News Shorts
New guidance for antibiotic use in rabbits

New best practice guidance on the responsible use of antibiotics in rabbits has been published by the BSAVA in collaboration with the Rabbit Welfare Association & Fund (RWA&F).

The guidance is free and has been produced to help veterinary practitioners select the most appropriate antibiotic for rabbits. It covers active substance, dose and route of administration all of which are crucial factors when treating rabbits owing to the risk of enterotoxaemia.

For more information and to access the guide, visit the BSAVALibrary.