Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Researchers improve speed and efficacy of rabies vaccine
The researchers designed a rabies vaccine that incorporated membrane-anchored BAFF to target B Cells directly.

Vaccine incorporates molecule to target B Cells directly
US researchers have found that adding a specific immune molecule to a rabies vaccine can improve its efficacy.

Writing in the journal PLOS Neglected Diseases, scientists note how they used a signalling protein called B Cell activating factor, which binds directly to B Cells.

Previous research found that the existing rabies vaccine works by activating the immune system’s B cells. However, the vaccine, which contains inactivated virus particles, can take some time to interact with the B cells.

In this study, the researchers designed a rabies vaccine that incorporated membrane-anchored BAFF to target B Cells directly. They then proceeded to test the vaccine on mice. 

Researchers found that the modified vaccine was significantly faster and had a stronger impact on the immune system compared to the standard vaccine.

“This new vaccine strategy significantly enhanced the speed and magnitude of the anti-rabies antibody responses and has the potential to improve the efficacy of currently used in activated RABV-based vaccines,” the authors wrote.

The study notes that more than 59,000 people die every year as a result of rabies, adding that existing vaccines to treat the disease are expensive and complicated to administer.

Scientists hope this new method could improve vaccine efficacy for a range of infectious diseases. However, further research is needed on the safety of the vaccine before it can be tested on humans.

The study was conducted by researchers at Thomas Jefferson University, Pennsylvania.

Become a member or log in to add this story to your CPD history

Nominations open for National Cat Awards 2020

News Story 1
 UK charity Cats Protection has announced that cat owners can nominate their pets for the National Cat Awards 2020 starting today.

The awards take place annually, celebrating heart warming stories of the positive impact that cats have on their owners. Cat owners have until Thursday 12 March to submit their nominations through the Cats Protection website. 

Click here for more...
News Shorts
Restriction zone lifted at Suffolk chicken farm

A one-kilometre restriction zone around a commercial chicken farm in mid-Suffolk has been lifted, following the completion of surveillance testing for avian influenza H5N3 with negative results.

Some 27,000 birds on the premises were culled after a veterinary surgeon identified the disease while investigating a fall in egg production. Poultry keepers are urged to take action to reduce the risk of disease in their flock by following government advice on biosecurity.