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Scientists set to develop animal-free model of human airways
It is hoped the project will prevent experiements on or with animals.
Model could prevent animal tests for toxicity of e-cigarettes

Scientists at Aston University are developing an animal-free model of the human airways, to be used for testing the toxicity of e-cigarettes.

It is hoped that the project, announced ahead of World No Tobacco Day (31 May), will prevent experiments on or with animals, as questions are raised about the long-term effects of e-cigarettes.

In the USA, such experiments are already taking place, in which animals are exposed to vapours for weeks or months on end. After the experiment, the animals are usually killed so that their tissues can be analysed.

The UK does not currently use animals to test e-cigarettes. If a manufacturer wanted to register them as an aid to quit smoking, however, they would be required under new regulations to have them tested as medicinal products, which may increase the chance of animal testing.

Jan Creamer, president of Animal Defenders International, which is funding the study, said: “Public outcry at smoking experiments led to them being ended, therefore the public, including those who vape, would be concerned to see animal tests for an alternative smoking product.

“We are excited to be funding the development of this innovative project which will save animals and provide accurate human-based data. It will also advance the way human cell lines can be maintained which could have far-reaching effects.”

Foetal calf serum (FCS) is the standard method used by researchers as the medium to grow human cell lines. However, this has raised ethical concerns owing to its collection method.

In this novel project, researchers will use multiple cell types submerged in medium without FCS. The cells will be tested and the results compared to previous data from cells grown with FCS.

The researchers will then test these cells under a “dynamic flow system” which more accurately mimics the environment in human airways. The model will then be used to see how the cells respond to e-cigarette exposure.

Project leader Dr Laura Leslie said: “The use of foetal calf serum to grow human cells, although currently standard practice, can present scientific challenges.

“By developing an entirely animal-free model, we hope to set the standard for a completely human-relevant method for investigating the effects of e-cigarettes on the human airways, an area where there is currently a lack of information.”

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New road sign to protect small wildlife

News Story 1
 Transport secretary Chris Grayling has unveiled a new road sign to help cut traffic accidents and protect small wildlife, particularly hedgehogs.

Local authorities and animal welfare groups are being asked to identify accident and wildlife hotspots where the sign - which features a hedgehog - should be located.

Government figures show that more than 600 people were injured in road accidents involving animals in 2017, and four people were killed. These figures do not include accidents involving horses. The new sign will be used to warn motorists in areas where there are large concentrations of small wild animals, including squirrels, badgers, otters and hedgehogs.  

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News Shorts
NOAH members re-elect Jamie Brannan as chair

Jamie Brannan, senior Vice President of Zoetis, has been re-elected as chair of NOAH for 2019/20, during this year’s AGM, held in London.

Mr Brannan joined Zoetis and the NOAH board in 2016, becoming NOAH’s vice-chair in 2018 and replacing Gaynor Hillier as chair later that year.

He commented: “I am extremely pleased to have been elected by the NOAH membership and am proud to be able to represent our industry at such a critical time for the UK animal health industry. I look forward to driving forward our new NOAH Strategy and to working with our members, old and new, in the coming year.”