Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Human anti-viral drug offers hope for cats
Bubba, one of the study cats, was diagnosed with abdominal non-effusive FIP. One week into the 12-week treatment course his owner reported he was ‘eating on his own, alert, energetic and playful.’

Field trial shows positive results in treating cats with FIP

An anti-viral drug used in human medicine has shown great promise in the treatment of a devastating infectious disease of cats.

One of the most promising treatments for emerging exotic viruses in humans is GS-5734. Studies have proved it to be effective in preventing ebola in rhesus monkeys and inhibiting coronaviruses in tissue culture and mouse model infections.

New research by the University of California (UC) Davis suggests the treatment could also offer hope to cats with feline infectious peritonitis (FIP), which is estimated to kill up to 1.4 per cent of cats around the world.

Initial studies studies by UC Davis found that GS-441524, which is the parent nucleoside of GS-5734, was highly effective against FIP. A field trial was subsequently carried out involving 26 cats with naturally-occurring FIP, which received at least 12 weeks of treatment.

The findings have been published in the Journal of Feline Medicine and Surgery (JFMS).

Researchers reported a ‘dramatic’ clinical response. Fever usually resolved in 12-36 hours and marked improvements were seen in appetite, activity levels and weight gain. In cats with the more common effusive or ‘wet’ form of the virus, abdominal effusions quickly disappeared from around day 10-14 after starting treatment.

Older cats, or those with non-effusive, or ‘dry’ FIP responded just as well to treatment as young cats and those with effusive FIP.

Currently, 24 of the 26 cats remain healthy, with one having succumbed to FIP and another to unrelated heart disease. In total, 18 of the cats received just one round of treatment, while the remaining eight suffered relapses of the disease. These were successfully treated with a second round of treatment at a higher dose. In two cases, a third round of treatment was needed.

Traditionally the prognosis for cats infected with FIP were bleak. In a review paper published in JFMS 10 years ago, the lead author for this study, Professor Niels Pedersen wrote: ‘No treatment has proven effective in curing cats of FIP, in spite of the claims. Cats that develop FIP inevitably die of the disease in days, weeks or months.’

However, following this latest study, as he approaches the end of his career, Prof Pedersen said: “FIP has been my fascination for the past 50 years and I am fortunate to have reached a final stage in my career having identified safe and effective antiviral drugs. We now know that small molecules targeting specific steps in RNA virus replication are capable of safely curing various forms of FIP.”

However, he cautioned that the field trial was for proof-of-concept and cannot yet be translated into commercially available drugs. He warned that the hope provided by these initial trials has increased the desperation of owners to acquire these drugs on the black market.

He added: “As eventful as these discoveries may be, there is still much more about FIP to discover.”

Image © Adel Gastle

Become a member or log in to add this story to your CPD history

Big Butterfly Count returns

News Story 1
 The world's biggest survey of butterflies is back for 2020!

Butterfly Conservation's Big Butterfly Count launches on Friday, 17 July and will run until Sunday 9 August. Members of the public can get involved by downloading the Big Butterfly Count App or recording results on a downloadable sheet available from bigbutterflycount.org/.

'It's a fantastic activity for people from three to 103 years and we'd encourage everyone to take 15 minutes in an appropriate outdoor space during sunny conditions to simply appreciate the nature around them and do their bit to help us understand butterfly populations,' said a Butterfly Conservation spokesperson. 

Click here for more...
News Shorts
WellVet reopens ticket sales to online conference platform

Following the success of its online conference, the organisers behind WellVet Weekend have re-opened ticket sales to allow new delegates to access session recordings and its online networking platform.

The day-long conference saw more than 360 veterinary professionals mix activity sessions with personal development CPD, all hosted within a virtual conference platform. Now, with more than 500 minutes of CPD available, the resource is being re-opened to allow full access to the session recordings until May 2021.

Sessions are aimed at providing delegates with a range of proactive wellbeing tools to explore to find ways of improving their mental and physical health. Tickets are limited in number and on sale at wellvet.co.uk until 30th August 2020.