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Bulldogs’ tails give insight into rare human disorder
Bulldogs, French bulldogs and Boston terries all share a feature not found in other breeds - a short, kinked tail or “screw tail”.
Scientists identify link between ‘screw tails’ and Robinow syndrome

Researchers in the US have made a link between the bulldog’s curly tail and a rare inherited disorder in humans.

Scientists from the University of California, Davis, School of Veterinary Medicine, found a common mutation in bulldogs and French bulldogs that is similar to genetic changes in the human disease, Robinow syndrome.

They believe that understanding this common mutation in these popular dog breeds could give more insight into this rare condition. The study has been published in the journal PLOS Genetics.

“It’s a very rare human disease but very common in dogs, so this could be a model for the human syndrome,” said professor Danika Bannash from UC Davis.

Bulldogs, French bulldogs and Boston terries all share a feature not found in other breeds - a short, kinked tail or “screw tail”. This is because all three breeds are missing the vertebrae that makes up the tail bone.

To learn more about the genetics associated with screw tail breeds, researchers analysed the genome of 100 dogs, of which 10 were screw tails.

From over 12 million individual differences, the researchers identified one mutation in a gene called DISHEVELLED 2 or DVL2. The variant was present in 100 per cent of the bulldogs and French bulldogs sampled, and it was also common in Boston terriers.

In humans, mutations in the related DVL1 and DVL3 genes are linked to Robinow syndrome - a disorder that causes a short, wide “babyface”, spinal deformities and short limbs - traits also shared by screw tail breeds.

The study also identified a key biochemical step in the pathway disrupted by the mutation, suggesting that a common molecular defect is responsible for the appearances of both Robinow patients and screw tail dog breeds. 

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Veterinary Evidence Student Awards winners revealed

News Story 1
 The first winners of the RCVS Knowledge Veterinary Evidence Student Awards have been revealed.

Molly Vasanthakumar scooped first prize for her knowledge summary comparing the ecological impact of woven versus disposable drapes. She found that there is not enough evidence that disposable synthetics reduce the risk of surgical site.

Second prize went to Honoria Brown of the University of Cambridge, for her paper: ‘Can hoof wall temperature and digital pulse pressure be used as sensitive non-invasive diagnostic indicators of acute laminitis onset?’

Edinburgh’s Jacqueline Oi Ping Tong won third prize for critically appraising the evidence for whether a daily probiotic improved clinical outcomes in dogs with idiopathic diarrhoea. The papers have all achieved publication in RCVS Knowledge’s peer-reviewed journal, Veterinary Evidence.  

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Animal Welfare Foundation seeks new trustees

The Animal Welfare Foundation (AWF) seeks three new trustees to help drive the charity’s mission to improve animal welfare through veterinary science, education and debate.

Veterinary and animal welfare professionals from across the UK may apply, particularly those with experience in equine and small animal practice and research management. Trustees must attend at least two meetings a year, as well as the annual AWF Discussion Forum in London.

For more information about the role, visit www.animalwelfarefoundation.org.uk. Applications close at midnight on 13 August 2019.