Your data on MRCVSonline
The nature of the services provided by Vision Media means that we might obtain certain information about you.
Please read our Data Protection and Privacy Policy for details.

In addition, (with your consent) some parts of our website may store a 'cookie' in your browser for the purposes of
functionality or performance monitoring.
Click here to manage your settings.
EmailIphone Application    Posted: 12th March 2024
If you would like to forward this story on to a friend, simply fill in the form below and click send.
Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Inbreeding leads to thoroughbred pregnancy loss, study finds
Inbreeding is commonly used in the breeding of livestock.

It contributed to mid and late-term pregnancy loss, but not early loss.

A new study has revealed that genomic inbreeding contributes to mid and late-term pregnancy loss (MLPL) in thoroughbred horses.

However the research, conducted by Royal Veterinary College (RVC), found that it had no contribution to early pregnancy loss (EPL).

The study saw researchers from RVC, in collaboration with Cornell University, analyse DNA samples from 189 horses, including a control group. The scientists studied the metrics of thoroughbred pregnancies that were lost in early, mid and late gestation.

Findings revealed thoroughbred pregnancies that were lost in mid and late gestation had significantly higher inbreeding metrics than in UK thoroughbred adults. In contrast, pregnancies which were lost early in gestation had no significant difference in inbreeding metrics to thoroughbred adults.

Inbreeding is commonly used in the breeding of livestock, to ensure that newborns carry desirable traits.

However, excessive inbreeding can increase the likelihood of uncovering homozygous recessive genotypes, which can be associated with a higher risk of retained placenta and lower semen quality in horses.

Five to 10 per cent of equine pregnancies result in pregnancy loss in the early stage of gestation. A further seven per cent are lost between Day 70 of gestation and 24 hours post parturition.

The findings of this study, which is the first to explore the effects of genomic inbreeding levels on late term pregnancy loss in horses. The researchers say that this highlights the importance of informed equine mating decisions to minimise the risk of miscarriages in thoroughbreds.

Dr Jessica Lawson, Alborada Trust Research Fellow at the RVC, said: “The take home from our work should be to carefully consider breeding choices that involve mating of highly related individuals as, ultimately, this may increase the chance of the foal inheriting mutations which may not be compatible with life.

“We are already working on the next step, looking to identify these changes so more specific advice can be provided in the future.”

The full study can be found in the Equine Veterinary Journal.

Image © Shutterstock

Become a member or log in to add this story to your CPD history

New guidelines published for wildlife disease surveillance

News Story 1
 A set of international guidelines for disease surveillance in wildlife has been updated for the first time since 2015.

Released by the International Union for Conservation of Nature and the World Organisation for Animal Health, General Guidelines for Surveillance of Diseases, Pathogens and Toxic Agents in Free-ranging Wildlife is designed to help wildlife authorities and others working with wildlife carry out effective surveillance programmes.

The document, which cover areas including choosing appropriate strategies, safety and biosafety protocols, and ethical and legal considerations, can be read here.  

Click here for more...
News Shorts
Restricted zone extended after more bluetongue cases

After three new cases of bluetongue virus serotype 3 were detected along the Hertfordshire and Buckinghamshire border, the restricted zone has been extended.

The zone now includes Buckinghamshire and part of Berkshire, as well as Bedfordshire, Cambridgeshire, City of Kingston upon Hull, East Riding of Yorkshire, East Sussex, Essex, Greater London, part of Hampshire, Hertfordshire, Kent, part of Leicestershire, Lincolnshire, Norfolk, part of Northamptonshire, Nottinghamshire, Suffolk, Surrey, and West Sussex.

Susceptible animals in the restricted zone should only be moved if it is essential. A specific licence is needed to move a susceptible animal from within the restricted zone to outside of the zone.

Bluetongue is a notifiable disease. Suspected cases must be reported on 03000 200 301 in England or 03003 038 268 in Wales. In Scotland, suspected cases should be reported to the local field services office. In Northern Ireland, suspected cases should be reported to the DAERA Helpline on 0300 200 7840 or by contacting the local DAERA Direct Veterinary Office.

A map of the areas where restrictions apply can be found here.