Your data on MRCVSonline
The nature of the services provided by Vision Media means that we might obtain certain information about you.
Please read our Data Protection and Privacy Policy for details.

In addition, (with your consent) some parts of our website may store a 'cookie' in your browser for the purposes of
functionality or performance monitoring.
Click here to manage your settings.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Thoroughbred fracture risk linked to collagen, study finds
This lack of collagen type III is a result of a change in their DNA sequence.

Horses with lower levels of collagen type III are at higher risk.

Researchers from the Royal Veterinary College (RVC) have developed a new genetic risk scoring system, after discovering new factors contributing to thoroughbred horses’ likelihood of fracture .

Their research revealed that thoroughbred horses with lower levels of collagen type III were at higher risk of fractures.

RVC’s research team, led by Dr Debbie Guest, developed a polygenic risk scoring system to measure horses’ disease risk. The system considers a variety of genes to assess the risk, which the team then used to look at the distribution of scores across the UK’s thoroughbred population.

Using this data, the researchers then selected cells from horses at either end of the risk spectrum to study further.

The cells were examined in a laboratory, to establish a cell model and find new genetic factors that may be involved in fracture risk.

The studies revealed that the horses with a higher risk of fracture also had lower levels of collagen type III. Collagen type III is a gene, found in their bone cells, which is required for normal bone formation.

The researchers say that this lack of collagen type III is a result of a change in their DNA sequence, in the region controlling how much collagen III is produced.

Further research will seek to validate the risk-scoring system using another group of horses. Studies will also use this system and cell model to identify any other genes and processes which may contribute to fracture susceptibility.

Dr Guest, project lead and senior research fellow at the RVC, said: “The development of a polygenic risk score for fracture will allow us to identify horses that are at high genetic risk to allow the targeted use of diagnostic imaging and close monitoring of their bone health.

“This study has also demonstrated the power of using cell models to work out what differences exist in bone cells from high and low-risk horses and therefore why some horses are at high risk.

“This is vital to develop new interventions for high-risk horses in the future so that they are less likely to suffer from a catastrophic fracture."

The full study can be found here.

Image © Shutterstock

Become a member or log in to add this story to your CPD history

Bristol uni celebrates 75 years of teaching vets

News Story 1
 The University of Bristol's veterinary school is celebrating 75 years of educating veterinary students.

Since the first group of students were admitted in October 1949, the school has seen more than 5,000 veterinary students graduate.

Professor Jeremy Tavare, pro vice-chancellor and executive dean for the Faculty of Health and Life Sciences, said: "I'm delighted to be celebrating Bristol Veterinary School's 75 years.

"Its excellence in teaching and research has resulted in greater understanding and some real-world changes benefiting the health and welfare of both animals and humans, which is testament to the school's remarkable staff, students and graduates." 

Click here for more...
News Shorts
RCVS HQ to temporarily relocate

The headquarters of the Royal College of Veterinary Surgeons (RCVS) is to move temporarily, ahead of its permanent relocation later in the year.

From Monday, 26 February 2024, RCVS' temporary headquarters will be at 2 Waterhouse Square, Holborn, London. This is within walking distance of its current rented offices at The Cursitor, Chancery Lane.

RCVS have been based at The Cursitor since February 2022, following the sale of its Westminster premises the previous March.

However, unforeseen circumstances relating to workspace rental company WeWork filing for bankruptcy means The Cursitor will no longer operate as a WeWork space. The new temporary location is still owned by WeWork.

RCVS anticipates that it will move into its permanent location at Hardwick Street, Clerkenwell, later on in the year.