Your data on MRCVSonline
The nature of the services provided by Vision Media means that we might obtain certain information about you.
Please read our Data Protection and Privacy Policy for details.

In addition, (with your consent) some parts of our website may store a 'cookie' in your browser for the purposes of
functionality or performance monitoring.
Click here to manage your settings.
EmailIphone Application    Posted: 31st October 2023
If you would like to forward this story on to a friend, simply fill in the form below and click send.
Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Research finds new immune-related genes in horses
The discovery contributes to our knowledge of how MHC genes affect horses' immune systems.

The discovery highlights diversity in immune system genes.

The University of Edinburgh’s Royal (Dick) School of Veterinary Studies have identified a range of newly uncovered gene sequences in horses’ immune systems.

The discovery of these new gene sequences reveals a larger variety of equine immune genes than were previously known, providing a stronger insight into the genetic makeup of horses and how they fight disease.

The researchers collaborated with scientists in England, Iceland and Norway to conduct analysis of genetic data from 168 horses, across three European breeds. The group used genetic sequencing technology to examine immune genes, known as Major Histocompatibility Complex (MHC), in Thoroughbred, Icelandic and Norwegian Fjords.

The analysis revealed a diversity in the immune systems’ genes when compared with horse populations which have evolved separately.

These gene sets come in two main types: MHCI and MHCII. Each type contains a complex arrangement of combinations which varies significantly per individual, supporting the immune system with recognising threats.

The analysis discovered 152 sequences of MHCI genes, which are responsible for monitoring infections within cells. It also found 117 new sequences of MHCII, which monitor for infections in surrounding cells.

There was a limited overlap in these gene types across the three horse breeds, which may mean that there is even greater MHC diversity in the global horse population.

Discovering these new genes may contribute to our knowledge of how MHC genes affect horses’ immune systems, as well as wider implications for clinical treatments.

It will also help with our understanding of equine health and disease, and inform breeding practices.

Dr Tim Connelley, research fellow at University of Edinburgh’s Roslin Institute, said: “We found a wide range of MHC genes and patterns of gene expression, allowing us to get a glimpse of how this set of genes may function in horses.

“These results could prove useful for vaccine development and novel cell-based therapies that are becoming more adopted in equine medicine."

The full study is published in the journal Cell.

Image © Shutterstock

Become a member or log in to add this story to your CPD history

Vetlife nominated for campaign award

News Story 1
 Vetlife has been shortlisted for the Association of Charity Organisations (ACO) Campaign of the Year Award 2024.

The nomination recognises its campaigning to raise awareness of neurodiversity within the profession and produce resources for individuals and workplaces. Vetlife's campaign has included talks, lived experience blogs, and an awareness video.

Kirstie Pickles, Vetlife trustee and project lead, said: "I am thrilled and delighted that the Vetlife neurodiversity awareness campaign has been shortlisted for the ACO Campaign of the Year Award 2024"

The winner will be announced 12 September 2024. 

Click here for more...
News Shorts
Northern Ireland chief vet warns of bluetongue risk

Following the detection of bluetongue virus serotype 3 (BTV-3) in England, Northern Ireland's chief veterinary officer has urged farmers to remain vigilant and source animals responsibly.

Brian Dooher said: "This confirmation in England is a stark reminder of the threat bluetongue presents to Northern Ireland.Whilst this finding in Norfolk is disappointing it is not unexpected giving the rising level of disease across several countries in Europe. Bluetongue does not affect human health or food safety, however an incursion to Northern Ireland would have a significant impact on livestock and the rural economy.

"I would like to remind all farmers of the importance of sourcing animals responsibly and ask that they maintain vigilance for signs of the disease reporting any suspicions to DAERA immediately."

Suspected cases of BTV-3 in Northern Ireland should be reported to the DAERA Helpline on 0300 200 7840 or by contacting the local DAERA Direct Veterinary Office.