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First case of Fragile Foal Syndrome found in thoroughbred horse
"While clearly a distressing condition for affected foals and their owners, the good news is that this lethal syndrome can be avoided with testing and careful mating selection" - Jessica Roach, PhD Student at the RVC.

The disorder was previously thought to affect only warmblood horses

A new study has discovered the first case of Fragile Foal Syndrome (FFS) in a thoroughbred horse, a condition previously found only in warmblood horses.

The collaborative study was carried out by the Royal Veterinary College (RVC), the University of California Davis Veterinary Genetics Laboratory (VGL) and Rossdales Laboratories, Newmarket. 

FFS is a connective tissue defect caused by a change in DNA within the procollagen-lysine, 2-oxoglutarate 5-dioxygenase1 (PLOD1) gene. It causes extensive skin lesions and musculoskeletal abnormalities, and the affected foals are aborted, stillborn or euthanised soon after birth owing to their condition.

As a autosomal recessive disorder, foals are affected if they have two copies of the mutation, so genetic testing is important for informing breeding decisions. This discovery is therefore particularly significant in highlighting the necessity of testing thoroughbred horses before breeding. 

PhD student at the RVC, Jessica Roach, said: “Pregnancy loss, stillbirth and neonatal death remain an important source of reproductive losses for horse breeders worldwide.

"Over the course of my PhD we have collated a large biobank of tissue and data from late term pregnancy losses through the generous co-operation of UK and Ireland TB stud farms and Rossdales Laboratories, Newmarket. 

“This has allowed us to explore the risk factors and pathology of many different causes of abortion and stillbirth. The collaboration with UC Davis and Lexi Grillos provided a fantastic opportunity to explore Fragile Foal Syndrome in our TB population and identify the first TB affected individual. 

“Whilst clearly a distressing condition for affected foals and their owners, the good news is that this lethal syndrome can be avoided with testing and careful mating selection.”

The study is published in Equine Veterinary Journal, and is available online at beva.onlinelibrary.wiley.com.

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Practices urged to audit neutering data

News Story 1
 RCVS Knowledge has called on vet practices to audit their post-operative neutering outcomes.

It follows the release of the 2024 NASAN benchmarking report, which collates data from neutering procedures performed on dogs, cats and rabbits.

The benchmarking report enables practices in the UK and Ireland to compare their post-operative outcomes to the national average. This includes the rate of patients lost to follow-up, which in 2024 increased to 23 per cent.

Anyone from the practice can submit the data using a free template. The deadline for next report is February 2026.

Visit the RCVS Knowledge website to complete an audit. 

Click here for more...
News Shorts
RCVS pays tribute to well-loved equine vet

The RCVS and the Riding Establishments Subcommittee has paid tribute to well-loved veterinary surgeon and riding establishment inspector, Rebecca Hamilton-Fletcher MRCVS.

Linda Belton MRCVS, RCVS President, said: "I, along with my colleagues on the RESC, RCVS Council, RCVS Standards Committee, as well as RCVS staff, was very saddened to hear of the sudden death of Rebecca, or Becca as we knew her, last week.

"She was a true advocate for equine welfare and in her many years on the RESC worked to continually improve the quality and consistency of riding establishment inspections, all in the interests of enhanced horse welfare and rider safety."