Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Researchers discover new gene defect that affects muzzle length in dogs
The American Staffordshire terrier (pictured) was one of the breeds found to possess both the normal and variant forms of the gene.

DLV2 variant may also affect development of the heart.

A recent study from the University of Helsinki has revealed new insights into the impact of a DVL2 gene defect on canine health. This gene variant is already associated with a screw tail and has become widespread in English bulldogs, French bulldogs and Boston terriers as a result of inbreeding.

Julia Niskanen from the University of Helsinki and the Folkhälsan Research Center said: “In this study, we wanted to further investigate the frequency of the DVL2 variant in different dog breeds and determine its effects on skeletal development.

The DVL2 variant was identified in all of the English bulldogs, French bulldogs and Boston terriers in the study, however, both the variant and the normal form were found in the American Staffordshire terriers, Staffordshire bull terriers, dogues de Bordeaux, olde English bulldogs and American bulldogs.

Using computed tomography scans, researchers analysed the skeletal anatomy of American Staffordshire bull terriers of different genotypes, in order to determine the effect of the variant gene on body shape. They found that the presence of the DVL2 gene defect commonly resulted in caudal vertebrae 'anomalies'.

“Tail abnormalities in the American Staffordshire terriers were less severe than the screw tails typically seen in English bulldogs, French bulldogs and Boston terriers,” added Vilma Reunanen from the University of Helsinki's Faculty of Veterinary Medicine.

“In contrast to the previous study, we did not find an association between the DVL2 variant and thoracic vertebral anomalies.”

Researchers also found that the muzzles of dogs that carry two copies of the gene defect are significantly shorter. Similarly, dogs with one copy of the defect have shorter muzzles than dogs that don’t carry any copies of the gene defect.

Several of the dogs with two copies DVL2 variant were found to have a congenital heart defect. However, researchers state that this finding requires further study.

Many of the breeds that carry the DVL2 variant also have other genetic variants that affect body shape. The study affirmed that the combined effects of these defects may result in 'serious health problems'.

Become a member or log in to add this story to your CPD history

Budding 'Dr Dolittles' sought for writing competition

News Story 1
 Vets are being invited to enter a writing competition run by the Page Turner Awards for a chance to get their story published or even made into a film.

Dubbed the 'Rolls Royce' of writing awards, the Page Turner competition provides an opportunity for aspiring writers to submit unpublished fiction and non-fiction work to be read by a panel of influential players in the publishing industry.

A spokesperson said: 'Do you think of yourself as a magical healer, like Dr Dolittle. Or maybe you have a story to share about the times when, sadly, animals can't be treated, and pet owners reflect on those moments they took for granted."

For more information, visit 

Click here for more...
News Shorts
Avian influenza confirmed in Lancashire

A case of highly pathogenic (HPAI H5N8) avian influenza has been confirmed in two captive peregrine falcons on a non-commercial, non-poultry premises near Skelmersdale, West Lancashire.

Following a risk assessment, APHA has declared that no disease control zones have been put in place surrounding this non-commercial, non-poultry premises.

Eighteen cases of HPAI H5N8 have now been identified in poultry and other captive birds in England. A housing order for poultry and captive birds introduced by Defra to control the spread of the disease expired on 31 March, although bird keepers in England are still required by law to comply with biosecurity measures.

For more information, please click here.