Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

More accurate technique for understanding joint behaviour
"I hope our method will contribute to uncovering the secrets of osteoarthritis in the future" - Dr Kamel Madi.
Technique measures joint strain under conditions mimicking normal use

Scientists have discovered a new technique for understanding joint behaviour in conditions like osteoarthritis with more accuracy than ever before.

The groundbreaking technique, published in Nature Research, employs high-resolution imaging and specially-designed software code to gain a deeper understanding of how joints react as osteoarthritis progresses.

Joint strain is traditionally measured on the nanometer scale on tissue structures such as collagen fibres, chondrocyte cells and bones.

Until now, such strains have only been measured at the sub-millimetre scale in whole joints during loading. In this study, scientists measured these strains in mouse knee joints with an accuracy greater than 100 nanometers - 1,000 times more precise than before.

The study involved male ‘STR/Ort’ mice, which develop a natural form of osteoarthritis with age, similar to the human disease. The researchers then compared these mice with male age-matched control mice that did not display any signs of age-related osteoarthritis.  

It used combination of x-ray tomography, a nano-precision loading frame and a software code designed to measure motion between subsequent 3D images with a resolution of 1/20th of a voxel (3D pixel).

Researchers found that in young, older and arthritic mice, changes in tissue structure and mechanical behaviour can be simultaneously visualised, and that tissue structure at the cellular level is comparative with the mechanical performance of the joint as a whole.

The collaborative study was conducted by researchers from the Royal Veterinary College (RVC), Edinburgh Napier University, University College London, Oregon State University (US), 3Dmagination and the Diamond Light Source.

RVC skeletal dynamics professor Andrew A Pitsillides, explained: “Our technique for nanometre scale measurement of real deformation in whole joints under conditions closely mimicking their normal use will, I hope, bring new understanding of joint behaviour in health and in osteoarthritis that devastates the lives of so many.”

3Dmagination Ltd director Dr Kamel Madi, added: “Measuring precise and reliable nanoscale strains in this complex biomedical system requires a perfect blend of skills, from in situ imaging to reconstruction and quantification of several terabytes of dataset, which is the team’s expertise at 3Dmagination Ltd.

“I am also passionate about bringing the images to life and I hope our method will contribute to uncovering the secrets of osteoarthritis in the future.”

Become a member or log in to add this story to your CPD history

Hill's Vet Nurse Awards 2020 - get your nominations in!

News Story 1
 Hill's Pet Nutrition are reminding all veterinary nurses and veterinary practices to submit their entries for its 'Pet Slimmer of the Year' competition, 'Managing Weight with Excellence Competition' and the 'Senior Support Nurse of the Year Competition'.

The deadline for the 'Senior Support Nurse of the Year' competition closes on 6 September 2020, while the other competitions will remain open until 14 September 2020. All finalists will have the chance to win up to 500 worth of Love to Shop Vouchers.

To see full terms & conditions or to enter the awards click here

Click here for more...
News Shorts
Webinar highlights increasing threat of Angiostrongylus vasorum and other nematodes

CPD provider elearning.vet has launched a free webinar highlighting the increasing threat of Angiostrongylus vasorum and other nematodes to human and animal health. Hosted by parasitologist Dr Ian Wright, head of ESCAAP UK, the webinar also discusses the most effective treatment and prevention strategies.

Dr Wright said: "With surveys showing deworming frequencies below those recommended by ESCCAP and concerns surrounding over treatment of cats and dogs, there has never been a more important time to examine the importance of routine roundworm prevention. Without adequate control of Toxocara canis and Angiostronglyus vasorum, the impact on owners and their pets can be considerable."