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Lung cancer in sheep offers clues to detection in humans
The virus infects the lungs of sheep and triggers the growth of cancerous cells
Advances in understanding may lead to new diagnostic tests

A new study, published recently in the Journal of Virology, has identified genetic changes occurring during the growth of lung cancer in sheep that improve understanding of how the disease develops. This could help lead to earlier diagnosis of the disease in sheep and in humans.

Ovine pulmonary adenocarcinoma (OPA) is an infectious and deadly lung disease of sheep, caused by the Jaagsiekte sheep retrovirus (JSRV). The virus infects the lung and triggers the growth of cancerous cells. Affected cells then produce more of the virus; which can infect new areas of the lung or spread to other sheep. While JSRV affects sheep and goats, it cannot be passed on to humans or other animals.

In affected flocks, OPA can result in the death of one to 20 per cent of the sheep in a year and poses a significant economic problem for farmers as a result. However, the reason why the sheep respond so badly to the virus is currently poorly understood.

The study, led by researchers from the Moredun Research Institute and the University of Edinburgh, looked at how lung cells change when infected with JSRV. It was found that cells related to the immune system and the formation of cancer had altered gene expression, which affects the production of proteins important for cell function.

“Understanding the genes that are switched on or off during JSRV infection provides important clues as to how the virus initiates cancer and may lead to novel routes for combating the disease,” said Dr David Griffiths of the Institute.

Investigating OPA also represents a valuable tool for studying some forms of human lung cancer, owing to similarities in how the cancer cells are activated in the sheep and human diseases.  By comparing their results on OPA to previously published data on human lung cancer, the research team found a large degree of overlap in the genes that were ‘faulty’.

Lung cancer is difficult to diagnose in its early stages in both sheep and humans and the discovery of common markers could lead to improved early detection of cancer in both sheep and humans.

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Kennel Club appoints new chief executive

News Story 1
 The Kennel Club has announced the appointment of Mark Beazley, who was previously Cats Protection's director of operations, as chief executive. Mark replaces Rosemary Smart, who stepped down from the role in April after 18 years.

Mark has held several senior strategic and executive roles, including executive director at Dogs Trust Ireland and chair of the Companion Animal Working Group at Eurogroup for Animals. He was also heavily involved in the establishment of the Eu Cat and Dog Alliance.

Mark will take up his new role in October. 

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International Cat Care appoints new head of veterinary division

International Cat Care (ICC) has announced the appointment of Nathalie Dowgray as head of the charity's veterinary division.

Nathalie, who is an RCVS advanced practitioner in feline medicine, will lead the International Society of Feline Medicine (ISFM) and a play key role in advancing knowledge and research in feline medicine.

Claire Bessant, iCatCare's chief executive said: "We're absolutely delighted to be welcoming Nathalie to the charity. She brings a depth and breadth of feline expertise and understanding which fits perfectly with the charity's work and development, and her enthusiasm for cats is infectious."