Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Scientists set to develop animal-free model of human airways
It is hoped the project will prevent experiements on or with animals.
Model could prevent animal tests for toxicity of e-cigarettes

Scientists at Aston University are developing an animal-free model of the human airways, to be used for testing the toxicity of e-cigarettes.

It is hoped that the project, announced ahead of World No Tobacco Day (31 May), will prevent experiments on or with animals, as questions are raised about the long-term effects of e-cigarettes.

In the USA, such experiments are already taking place, in which animals are exposed to vapours for weeks or months on end. After the experiment, the animals are usually killed so that their tissues can be analysed.

The UK does not currently use animals to test e-cigarettes. If a manufacturer wanted to register them as an aid to quit smoking, however, they would be required under new regulations to have them tested as medicinal products, which may increase the chance of animal testing.

Jan Creamer, president of Animal Defenders International, which is funding the study, said: “Public outcry at smoking experiments led to them being ended, therefore the public, including those who vape, would be concerned to see animal tests for an alternative smoking product.

“We are excited to be funding the development of this innovative project which will save animals and provide accurate human-based data. It will also advance the way human cell lines can be maintained which could have far-reaching effects.”

Foetal calf serum (FCS) is the standard method used by researchers as the medium to grow human cell lines. However, this has raised ethical concerns owing to its collection method.

In this novel project, researchers will use multiple cell types submerged in medium without FCS. The cells will be tested and the results compared to previous data from cells grown with FCS.

The researchers will then test these cells under a “dynamic flow system” which more accurately mimics the environment in human airways. The model will then be used to see how the cells respond to e-cigarette exposure.

Project leader Dr Laura Leslie said: “The use of foetal calf serum to grow human cells, although currently standard practice, can present scientific challenges.

“By developing an entirely animal-free model, we hope to set the standard for a completely human-relevant method for investigating the effects of e-cigarettes on the human airways, an area where there is currently a lack of information.”

Become a member or log in to add this story to your CPD history

Endangered turtles rescued from smugglers

News Story 1
 A group of endangered turtles have found a new home at London Zoo after being rescued from smugglers.

The four big-headed turtles arrived at the zoo at the end of last year, after smugglers tried to illegally import them to Canada, labelled as toys.

One of the turtles, named Lady Triệu after a Vietnamese warrioress, has moved to a new exhibit in the zoo’s reptile house. She is the only one of her kind in a UK zoo.

Big-headed turtles have such large heads that they cannot pull them back into their shells. To compensate, they have armour plating from head to tail and a very sharp beak to fend off predators. They are ranked number 18 on ZSL’s EDGE of Existence reptile list, which puts threatened species at the forefront of conservation action. Image © ZSL  

Click here for more...
News Shorts
Professor Abdul Rahman announced as keynote speaker for BVA Members’ Day 2019

Celebrated Indian vet and parasitologist Professor Abdul Rahman is set to deliver the keynote speech at BVA Members’ Day 2019.

Professor Rahman will present his insights into the human behaviour challenges of controlling zoonotic disease in his talk: ‘A One Health approach to rabies elimination in Asia’. The talk will outline efforts to gain political support for dog vaccination programmes in China, as well as the need for a collaborative approach between vets, public health, livestock and animal welfare agencies.

The event takes place on Thursday, 19 September at Brangwyn Hall, Swansea. Tickets are free but must be reserved through the BVA website as places are limited.