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DNA mutation linked to breathing issues in dogs
The mutated version of the ADAMTS3 gene was common in French and English bulldogs, scientists found.
Status of ADAMTS3 gene ‘should be considered’ alongside skull shape

Scientists have discovered a DNA mutation that is linked to breathing problems in dogs, including brachycephalic breeds.

Difficulty breathing is generally associated with breeds such as pugs, English bulldogs and French bulldogs. However, scientists have said the mutation is also carried by Norwich terriers, which have proportional noses.

A research team led by the Roslin Institute analysed DNA from more than 400 Norwich terriers. Vets also carried out clinical examinations of the dogs’ airways to check for signs of disease.

A mutation was found in the ADAMTS3 gene, which is not linked to skull shape but has previously been found to cause fluid retention and swelling. The mutated version of the gene was also common in French and English bulldogs, which researchers say could explain why some dogs suffer breathing issues and complications after surgery to correct the problem.

Researchers suggested that fluid retention in the tissue that lines the airways could result in breathing problems for dogs with the mutation. The findings have been published in the journal PLOS Genetics.

Popular flat-faced breeds, such as pugs and French bulldogs, are known to be commonly affected by brachycephalic obstructive airway syndrome (BOAS). Scientists previously thought their extreme facial conformation was the only explanation for their breathing problems, but Norwich terriers suffer from a similar problem called upper airway syndrome.

Lead author Dr Jeffrey Schoenebeck said: “BOAS is a complex disease. Although skull shape remains an important risk factor, our study suggests that the status of ADAMTS3 should be considered as well. More studies are needed to dissect the complex nature of this devastating disease.”

The findings could lead to genetic tests that could help vets identify at-risk animals, helping breeders to avoid producing affected puppies.

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Practices urged to audit neutering data

News Story 1
 RCVS Knowledge has called on vet practices to audit their post-operative neutering outcomes.

It follows the release of the 2024 NASAN benchmarking report, which collates data from neutering procedures performed on dogs, cats and rabbits.

The benchmarking report enables practices in the UK and Ireland to compare their post-operative outcomes to the national average. This includes the rate of patients lost to follow-up, which in 2024 increased to 23 per cent.

Anyone from the practice can submit the data using a free template. The deadline for next report is February 2026.

Visit the RCVS Knowledge website to complete an audit. 

Click here for more...
News Shorts
New guidance for antibiotic use in rabbits

New best practice guidance on the responsible use of antibiotics in rabbits has been published by the BSAVA in collaboration with the Rabbit Welfare Association & Fund (RWA&F).

The guidance is free and has been produced to help veterinary practitioners select the most appropriate antibiotic for rabbits. It covers active substance, dose and route of administration all of which are crucial factors when treating rabbits owing to the risk of enterotoxaemia.

For more information and to access the guide, visit the BSAVALibrary.