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DNA mutation linked to breathing issues in dogs
The mutated version of the ADAMTS3 gene was common in French and English bulldogs, scientists found.
Status of ADAMTS3 gene ‘should be considered’ alongside skull shape

Scientists have discovered a DNA mutation that is linked to breathing problems in dogs, including brachycephalic breeds.

Difficulty breathing is generally associated with breeds such as pugs, English bulldogs and French bulldogs. However, scientists have said the mutation is also carried by Norwich terriers, which have proportional noses.

A research team led by the Roslin Institute analysed DNA from more than 400 Norwich terriers. Vets also carried out clinical examinations of the dogs’ airways to check for signs of disease.

A mutation was found in the ADAMTS3 gene, which is not linked to skull shape but has previously been found to cause fluid retention and swelling. The mutated version of the gene was also common in French and English bulldogs, which researchers say could explain why some dogs suffer breathing issues and complications after surgery to correct the problem.

Researchers suggested that fluid retention in the tissue that lines the airways could result in breathing problems for dogs with the mutation. The findings have been published in the journal PLOS Genetics.

Popular flat-faced breeds, such as pugs and French bulldogs, are known to be commonly affected by brachycephalic obstructive airway syndrome (BOAS). Scientists previously thought their extreme facial conformation was the only explanation for their breathing problems, but Norwich terriers suffer from a similar problem called upper airway syndrome.

Lead author Dr Jeffrey Schoenebeck said: “BOAS is a complex disease. Although skull shape remains an important risk factor, our study suggests that the status of ADAMTS3 should be considered as well. More studies are needed to dissect the complex nature of this devastating disease.”

The findings could lead to genetic tests that could help vets identify at-risk animals, helping breeders to avoid producing affected puppies.

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Endangered turtles rescued from smugglers

News Story 1
 A group of endangered turtles have found a new home at London Zoo after being rescued from smugglers.

The four big-headed turtles arrived at the zoo at the end of last year, after smugglers tried to illegally import them to Canada, labelled as toys.

One of the turtles, named Lady Triệu after a Vietnamese warrioress, has moved to a new exhibit in the zoo’s reptile house. She is the only one of her kind in a UK zoo.

Big-headed turtles have such large heads that they cannot pull them back into their shells. To compensate, they have armour plating from head to tail and a very sharp beak to fend off predators. They are ranked number 18 on ZSL’s EDGE of Existence reptile list, which puts threatened species at the forefront of conservation action. Image © ZSL  

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Professor Abdul Rahman announced as keynote speaker for BVA Members’ Day 2019

Celebrated Indian vet and parasitologist Professor Abdul Rahman is set to deliver the keynote speech at BVA Members’ Day 2019.

Professor Rahman will present his insights into the human behaviour challenges of controlling zoonotic disease in his talk: ‘A One Health approach to rabies elimination in Asia’. The talk will outline efforts to gain political support for dog vaccination programmes in China, as well as the need for a collaborative approach between vets, public health, livestock and animal welfare agencies.

The event takes place on Thursday, 19 September at Brangwyn Hall, Swansea. Tickets are free but must be reserved through the BVA website as places are limited.