Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

Genetically-modified chickens offer hope for cheaper drugs
Chickens could be used as a cheaper method for producing high-quality research drugs.

New method produces therapeutic proteins as part of the egg white

Researchers at the University of Edinburgh’s Roslin Institute have genetically-modified chickens to produce human proteins in their eggs.

It is hoped the method could one day offer a cost-effective solution for producing certain drugs, including therapies for treating cancer.

The team found that high quantities of the proteins needed for the drugs could be recovered from each egg using a purification system. The drugs they recovered worked as well as if the same proteins were produced using existing methods.

Their findings suggest that chickens could be used as a cheaper method for producing high-quality research drugs. Looking ahead it is also hoped that the drugs could be used in patients.

The team set out to produce high-quality proteins for use in scientific research. They did not witness any adverse effects on the chickens themselves, which continued to lay eggs as normal.

Scientists already use eggs to produce vaccinations, such as the influenza vaccine. But the new method differs because the proteins are produced as part of the egg white.

In this study, three eggs were enough to develop a dose of the drug that is clinically relevant. With chickens laying up to around 300 eggs per year, researchers say the approach could be more cost-effective than current methods.

The two proteins the team have been focusing on are IFNalpha2a, which has powerful anti-cancer and anti-inflammatory effects, and macrophage-CSF, which can stimulate the repair of damaged tissues.

Professor Helen Sang of the Roslin Institute said: “We are not yet producing medicines for people, but this study shows that chickens are commercially viable for producing proteins suitable for drug discovery studies and other applications in biotechnology.”

Dr Lissa Herron, head of the Avian Biopharming Business Institute at Roslin Technologies, added: “We are excited to develop this technology to its full potential, not just for human therapies in the future but also in the fields of research and animal health.”

The findings are published in the journal BMC Biotechnology. 

Become a member or log in to add this story to your CPD history

Stephen Fry lends voice to frog conservation film

News Story 1
 Comedian and author Stephen Fry has lent his voice to a new animation that hopes to raise awareness of deadly ranavirus, which is threatening the UK’s frogs.

Research by ZSL, who created the short film, suggests that at least 20 per cent of ranavirus cases over the past three decades, could be attributed to human introductions. This includes pond owners introducing fish, frog spawn and plants from other environments.

Amphibian disease expert Dr Stephen Price said: “People can help stop the spread by avoiding moving potentially infected material such as spawn, tadpoles, pond water and plants into their own pond. Disinfecting footwear or pond nets before using them elsewhere will also help.” 

Click here for more...
News Shorts
Scotland to fund OV training

The Scottish Government has revealed it will fund training for new Official Veterinarians (OVs), covering the Essential Skills, Statutory Surveillance and TB Testing.

Funding will also be provided for the revalidation of Essential Skills, as well as TB Testing for existing OVs. This is the second round of financial support from the Scottish Government for OVs.

BVA president Simon Doherty said he is “delighted” with the announcement.

“Official Veterinarians’ work in safeguarding animal health and welfare and ensuring food safety is invaluable,” he added. “This announcement has come at a crucial time, with Brexit and an uncertain future ahead, the role of OVs will be more important than ever in enabling the UK’s trade in animal products.