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Researchers discover new gene defect that affects muzzle length in dogs
The American Staffordshire terrier (pictured) was one of the breeds found to possess both the normal and variant forms of the gene.

DLV2 variant may also affect development of the heart.

A recent study from the University of Helsinki has revealed new insights into the impact of a DVL2 gene defect on canine health. This gene variant is already associated with a screw tail and has become widespread in English bulldogs, French bulldogs and Boston terriers as a result of inbreeding.

Julia Niskanen from the University of Helsinki and the Folkhälsan Research Center said: “In this study, we wanted to further investigate the frequency of the DVL2 variant in different dog breeds and determine its effects on skeletal development.

The DVL2 variant was identified in all of the English bulldogs, French bulldogs and Boston terriers in the study, however, both the variant and the normal form were found in the American Staffordshire terriers, Staffordshire bull terriers, dogues de Bordeaux, olde English bulldogs and American bulldogs.

Using computed tomography scans, researchers analysed the skeletal anatomy of American Staffordshire bull terriers of different genotypes, in order to determine the effect of the variant gene on body shape. They found that the presence of the DVL2 gene defect commonly resulted in caudal vertebrae 'anomalies'.

“Tail abnormalities in the American Staffordshire terriers were less severe than the screw tails typically seen in English bulldogs, French bulldogs and Boston terriers,” added Vilma Reunanen from the University of Helsinki's Faculty of Veterinary Medicine.

“In contrast to the previous study, we did not find an association between the DVL2 variant and thoracic vertebral anomalies.”

Researchers also found that the muzzles of dogs that carry two copies of the gene defect are significantly shorter. Similarly, dogs with one copy of the defect have shorter muzzles than dogs that don’t carry any copies of the gene defect.

Several of the dogs with two copies DVL2 variant were found to have a congenital heart defect. However, researchers state that this finding requires further study.

Many of the breeds that carry the DVL2 variant also have other genetic variants that affect body shape. The study affirmed that the combined effects of these defects may result in 'serious health problems'.

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Webinar to focus on equine worm control

News Story 1
 Vets, veterinary nurses and RAMAs are being invited to join a free CPD webinar on late winter and early spring equine worm control.

Hosted by Zoetis vet Dr Wendy Talbot, the webinar aims to help prescribers understand which parasites are of most concern at this time of year. It will also cover how to assess parasite risk, selecting a suitable wormer and spring wormer plans, concluding with a Q&A session.

The webinar takes place on Thursday, 18 March at 10 am and will be repeated at 7 pm for those unable to listen during the day. To book the 10 am webinar, click here, and to register for the 7 pm webinar, click here

Click here for more...
News Shorts
Avian influenza confirmed in Lancashire

A case of highly pathogenic (HPAI H5N8) avian influenza has been confirmed in two captive peregrine falcons on a non-commercial, non-poultry premises near Skelmersdale, West Lancashire.

Following a risk assessment, APHA has declared that no disease control zones have been put in place surrounding this non-commercial, non-poultry premises.

Eighteen cases of HPAI H5N8 have now been identified in poultry and other captive birds in England. A housing order for poultry and captive birds introduced by Defra to control the spread of the disease expired on 31 March, although bird keepers in England are still required by law to comply with biosecurity measures.

For more information, please click here.