Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
 
 
Send Cancel

RVC study reveals insights on tendon disease
“Our results show that proteins within tendon are renewed much more rapidly than previously thought" - Dr Chavaunne Thorpe.
Scientists examined protein turnover rates in the tendons of rats.

New treatments for tendon disease and other musculoskeletal disorders could be on the horizon thanks to research by the Royal Veterinary College (RVC).

In the study, scientists examined protein turnover rates in the tendons of rats and found that tendons are dynamic tissue with varying turnover rates of proteins.

It is hoped the discovery could eventually provide a greater understanding of how tendon disease and other connective tissue disorders can be treated.

Dr Chavaunne Thorpe, Versus Arthritis Career Development Fellow at the RVC and author of the paper, explains: “Our results show that proteins within tendon are renewed much more rapidly than previously thought, with different rates of turnover in different regions of the tendon.

“These findings will help us to understand how the rate of protein renewal in tendon is affected by ageing or injury and will allow future studies to identify potential targets for treatment of tendon disease and other prominent diseases which are caused by alterations in protein turnover rates.”

The study built on previous research that found that the interfascicular matrix - the main load-bearing structures of the tendon - allows sliding between fascicles, meaning that it may be prone to damage.

In this latest study, scientists sought to establish if the turnover rate of proteins in the interfascicular matrix is greater than in the fascicles, which would help repair any damage. The results are published in the journal Structural Biology and Molecular Biophysics.

'The discovery challenges long-held beliefs that almost no protein turnover occurs in tendon and instead, provides the first step in understanding how altered protein turnover contributes to the development of tendon disease,' the researchers note.

'Additionally, with alterations in protein turnover rates contributing to other musculoskeletal and connective tissue diseases, this study will also help target future research into how these diseases can most effectively be treated.'

Become a member or log in to add this story to your CPD history

New 'DoggyLottery' to raise funds for rescue centres

News Story 1
 A new 'DoggyLottery' to raise funds for dog rescue centres in the UK will launch on Saturday (4 July). Every four weeks, five different rescue centres will be connected to the lottery, providing much-needed funds - particularly during COVID-19 - and providing vital online exposure.

A weekly game costs £1.50 and entrants will have the chance of being one of 20 guaranteed winners. A massive 60 per cent of the raised funds will go towards the dog rescue centres, more than double that donated by leading lottery companies to charitable causes.

To find out more and play the lottery, visit www.doggylottery.co.uk  

Click here for more...
News Shorts
International Cat Care appoints new head of veterinary division

International Cat Care (ICC) has announced the appointment of Nathalie Dowgray as head of the charity's veterinary division.

Nathalie, who is an RCVS advanced practitioner in feline medicine, will lead the International Society of Feline Medicine (ISFM) and a play key role in advancing knowledge and research in feline medicine.

Claire Bessant, iCatCare's chief executive said: "We're absolutely delighted to be welcoming Nathalie to the charity. She brings a depth and breadth of feline expertise and understanding which fits perfectly with the charity's work and development, and her enthusiasm for cats is infectious."