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Dog genome project makes first discovery
Researchers have discovered a new genetic mutation that causes progressive retinal atrophy in Shetland sheepdogs.

New DNA test to help breeders reduce PRA in Shetland sheepdogs

A new genetic mutation that causes progressive retinal atrophy (PRA) in Shetland sheepdogs has been discovered by researchers at the UK’s largest canine genome health bank.


The disease mutation, named BBS2-PRA, is the first to be discovered as a direct result of the Give a Dog a Genome project, led by the Kennel Club Genetics Centre at the Animal Health Trust (AHT). The team has already developed a DNA test to help identify affected and carrier dogs, which will be available from Thursday, 5 March.

“It is always exciting to discover a new mutation that causes an inherited disease in dogs because it provides a means for breeders to reduce the frequency of the mutation in future generations of dogs and, very importantly, to avoid breeding clinically affected dogs,” said Dr Cathryn Mellersh, head of the Kennel Club Genetics Centre at the AHT.


“But the discovery of the mutation that causes BBS2-PRA in Shetland Sheepdogs is particularly exciting because it is the first disease mutation we have discovered as a direct result of our Give a Dog a Genome project.”

PRA is a recognised condition within Shetland sheepdogs, but until now the mutation causing this form had not been identified. Besides PRA, dogs with the BBS2-PRA mutation have an upturned nose, an unusual coat texture which is wavy in appearance and dental defects.

The Give a Dog a Genome project utilises whole genome sequencing technology to make the mutation identification process faster and more efficient.

Previously, researchers would conduct a lengthy Genome-Wide Association Study (GWAS) to identify a region of the genome that harboured the disease mutation, followed by sequencing methods to pinpoint the causal mutation. 
 For a disease like PRA, this would involve using DNA from between 12 and 20 individual dogs.

Through the Give a Dog a Genome DNA database, the AHT was able to compare the DNA of just one Shetland sheepdog with PRA with the genomes of other dogs to successfully identify the mutation that causes PRA in this breed.

“Being able to identify a disease mutation from a very small number of dogs means that we can make a DNA test available much earlier in the process of disease emergence, ideally before the mutation has had the chance to become widespread throughout the breed,” explained research assent Rebekkah Hitti-Malin.


“In turn, this means that the mutation can be eliminated from the breed population more quickly, possibly within just a few generations of the DNA test being launched.”

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Vets to run marathon for World Animal Protection

News Story 1
 Two recently graduated veterinary surgeons will be running the London Marathon in April to raise money for the charity World Animal Protection.

Alex Bartlett and Maeve O'Neill plan to run the race together if they are given the same start times.

Dr O'Neill said: "You're always limited in what you can do to help animals, so it is nice to raise money for a charity that helps animals around the world."

Dr Bartlett added: "I have never run a marathon before and am excited to run my first one for such a good cause!"

Both Dr Bartlett and Dr O'Neill have fundraising pages online. 

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News Shorts
BSAVA releases new Guide to Procedures

The British Small Animal Veterinary Association (BSAVA) has published a new edition of its Guide to Procedures for Small Animal Practice.

It has added four new procedures; cystostomy tube placement, endotracheal intubation, point-of-care ultrasound and wet-to-dry dressings.

BSAVA says that it is an essential step-by-step guide to diagnostic and therapeutic procedures performed in practice. The textbook includes new images and illustrations, as well as high-definition videos for use prior to procedures.

Nick Bexfield and Julia Riggs, editors of the new edition, said: "We have built upon the success of the previous editions by responding to the feedback received from the BSAVA readership, and hope this new guide helps to further increase the confidence and accuracy with which these procedures are performed."

Print copies are available in the BSAVA store, with a digital version in the BSAVA library.