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Lung cancer in sheep offers clues to detection in humans
The virus infects the lungs of sheep and triggers the growth of cancerous cells
Advances in understanding may lead to new diagnostic tests

A new study, published recently in the Journal of Virology, has identified genetic changes occurring during the growth of lung cancer in sheep that improve understanding of how the disease develops. This could help lead to earlier diagnosis of the disease in sheep and in humans.

Ovine pulmonary adenocarcinoma (OPA) is an infectious and deadly lung disease of sheep, caused by the Jaagsiekte sheep retrovirus (JSRV). The virus infects the lung and triggers the growth of cancerous cells. Affected cells then produce more of the virus; which can infect new areas of the lung or spread to other sheep. While JSRV affects sheep and goats, it cannot be passed on to humans or other animals.

In affected flocks, OPA can result in the death of one to 20 per cent of the sheep in a year and poses a significant economic problem for farmers as a result. However, the reason why the sheep respond so badly to the virus is currently poorly understood.

The study, led by researchers from the Moredun Research Institute and the University of Edinburgh, looked at how lung cells change when infected with JSRV. It was found that cells related to the immune system and the formation of cancer had altered gene expression, which affects the production of proteins important for cell function.

“Understanding the genes that are switched on or off during JSRV infection provides important clues as to how the virus initiates cancer and may lead to novel routes for combating the disease,” said Dr David Griffiths of the Institute.

Investigating OPA also represents a valuable tool for studying some forms of human lung cancer, owing to similarities in how the cancer cells are activated in the sheep and human diseases.  By comparing their results on OPA to previously published data on human lung cancer, the research team found a large degree of overlap in the genes that were ‘faulty’.

Lung cancer is difficult to diagnose in its early stages in both sheep and humans and the discovery of common markers could lead to improved early detection of cancer in both sheep and humans.

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Nominations open for National Cat Awards 2020

News Story 1
 UK charity Cats Protection has announced that cat owners can nominate their pets for the National Cat Awards 2020 starting today.

The awards take place annually, celebrating heart warming stories of the positive impact that cats have on their owners. Cat owners have until Thursday 12 March to submit their nominations through the Cats Protection website. 

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Restriction zone lifted at Suffolk chicken farm

A one-kilometre restriction zone around a commercial chicken farm in mid-Suffolk has been lifted, following the completion of surveillance testing for avian influenza H5N3 with negative results.

Some 27,000 birds on the premises were culled after a veterinary surgeon identified the disease while investigating a fall in egg production. Poultry keepers are urged to take action to reduce the risk of disease in their flock by following government advice on biosecurity.