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Lung cancer in sheep offers clues to detection in humans
The virus infects the lungs of sheep and triggers the growth of cancerous cells
Advances in understanding may lead to new diagnostic tests

A new study, published recently in the Journal of Virology, has identified genetic changes occurring during the growth of lung cancer in sheep that improve understanding of how the disease develops. This could help lead to earlier diagnosis of the disease in sheep and in humans.

Ovine pulmonary adenocarcinoma (OPA) is an infectious and deadly lung disease of sheep, caused by the Jaagsiekte sheep retrovirus (JSRV). The virus infects the lung and triggers the growth of cancerous cells. Affected cells then produce more of the virus; which can infect new areas of the lung or spread to other sheep. While JSRV affects sheep and goats, it cannot be passed on to humans or other animals.

In affected flocks, OPA can result in the death of one to 20 per cent of the sheep in a year and poses a significant economic problem for farmers as a result. However, the reason why the sheep respond so badly to the virus is currently poorly understood.

The study, led by researchers from the Moredun Research Institute and the University of Edinburgh, looked at how lung cells change when infected with JSRV. It was found that cells related to the immune system and the formation of cancer had altered gene expression, which affects the production of proteins important for cell function.

“Understanding the genes that are switched on or off during JSRV infection provides important clues as to how the virus initiates cancer and may lead to novel routes for combating the disease,” said Dr David Griffiths of the Institute.

Investigating OPA also represents a valuable tool for studying some forms of human lung cancer, owing to similarities in how the cancer cells are activated in the sheep and human diseases.  By comparing their results on OPA to previously published data on human lung cancer, the research team found a large degree of overlap in the genes that were ‘faulty’.

Lung cancer is difficult to diagnose in its early stages in both sheep and humans and the discovery of common markers could lead to improved early detection of cancer in both sheep and humans.

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Regional Representatives nominations sought

News Story 1
 Seven new regional representatives are being sought by the British Veterinary Association (BVA) to speak for vets from those regions and to represent their views to BVA Council.

The opportunities are available in in the North-East, Yorkshire & Humber, East Midlands, West Midlands, London, Wales, and Northern Ireland. Representatives from all sectors of the veterinary profession are urged to apply.

BVA president Daniella Dos Santos, said: "Our regional representatives are integral to that mission and to the activities of Council - contributing to effective horizon scanning on matters of veterinary policy and providing an informed steer to BVA’s Policy Committee.” 

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Livestock Antibody Hub receives funding boost

The Pirbright Institute has received US $5.5 million from the Bill and Melinda Gates Foundation to form a Livestock Antibody Hub aimed at supporting animal and human health. The work will bring together researchers from across the UK utilise research outcomes in livestock disease and immunology.

Dr Doug Brown, chief executive of the British Society for Immunology, commented: “The UK is a world leader in veterinary immunology research, and this transformative investment from the Bill & Melinda Gates Foundation will drive the next chapter of innovation in developing new treatments and prevention options against livestock diseases".