Cookie use on MRCVSonline
We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive all cookies.
If you would like to forward this story on to a friend, simply fill in the form below and click send.

Your friend's email:
Your email:
Your name:
Send Cancel

Salmonella study reveals how genetic changes alter disease risk
The U288 variant was found to have undergone a unique set of genetic changes, most likely between 1980 and 2000.

Variants found in pigs pose different threats to human and animal health.

A new study from the Roslin Institute and the Quadram Institute has found that two closely related variants of salmonella typhimurium have significantly different effects on pig health compared to other animals and humans.

The study, published in the journal Communications Biology, analysed the genetic makeup of salmonella strains found in pigs and people over a number of years, with the aim of identifying variants and understanding how they evolved and behave.

The two variants, named U288 and ST34, were predominantly found in pigs and differences were found in both variants' colonisation of the intestine and surrounding tissues as well as the severity of disease they created.

According to the researchers, the ST34 variant accounts for more than half of all salmonella typhimurium infections in people, while the U288 variant is rarely associated with human infection.

The U288 variant was found to have undergone a unique set of genetic changes, most likely between 1980 and 2000. It evolved to obtain genes associated with antimicrobial resistance, as well as variations in molecules connected to virulence.

The researchers suggest that these changes could hold the key to understanding how this variant interacts differently with pigs during infections and in the food chain.

Professor Mark Stevens from the Roslin Institute said: “Understanding how variants of Salmonella emerge and pinpointing the genetic signatures responsible for adaptation to different hosts and the ability to produce disease will provide opportunities to improve diagnostics and surveillance. In turn this will help to predict the risk that Salmonella variants pose to animal health and food safety.”

Become a member or log in to add this story to your CPD history

VetCT app offered to students and new graduates

News Story 1
 The VetCT app is being offered for free to students and new veterinary graduates for their first three months in practice. The app provides a service for vets to send case information to a global team of Diploma-holding specialists, who can provide advice and support via instant call-back, text chat, written report, or virtual appointment.

Time on the app is automatically logged as CPD with quarterly certificates being generated for users. Additional services include the ability to book bespoke CPD, significant event reviews, and live training sessions such as surgical procedures.

The app is downloadable for both iOS and Android systems. 

Click here for more...
News Shorts
HORIBA to host CPD webinar

HORIBA has announced that it will host an online CPD meeting focusing on 'Exotic Parasites - The Importance of Testing in The Imported Dog'. Ian Wright (BVMS, MSc, MRCVS), head of ESCCAP UK and Ireland, will present on the importance of testing protocols in diseases of imported dogs.

The meeting will provide attendees with an overview of emerging veterinary diseases with a particular focus on exotic parasites, and discuss the importance of accurate testing protocols and equipment, alongside a final Q&A session.

The webinar will take place on Thursday July 1, from 19.30pm to 21.00pm BST. For free registration and more information visit the Horiba website or